FIELD: biochemistry.
SUBSTANCE: invention relates to a rodent having in its genome a deletion of a region from a full coding part of exon 2 to a coding part of exon 11 of an endogenous locus C9orf72 , a cell, tissue, an embryo, as well as a method for production thereof. Also disclosed is a method for identifying a therapeutic candidate for treating (i) one or more symptoms of dysregulation or dysfunction of the immune system, (ii) neurological abnormalities or (iii) a combination thereof, using said rodent.
EFFECT: invention makes it possible to efficiently create model on rodent, which reproduces neurodegenerative and/or inflammatory disease of human.
34 cl, 10 dwg, 6 tbl, 4 ex
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| ANIMALS, OTHER THAN HUMANS, WITH DISTURBANCE IN LOCUS C9orf72 | 2016 |
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| ANIMALS OTHER THAN HUMANS CHARACTERIZED IN EXPANSION OF HEXANUCLEOTIDE REPEATS AT LOCUS C9orf72 | 2017 |
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| ANIMALS OTHER THAN HUMANS WITH CONSTRUCTED LOCUS OF LIGHT LAMBDA CHAIN OF IMMUNOGLOBULIN | 2017 |
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| NON-HUMAN ANIMALS HAVING HUMANIZED SIGNAL-REGULATORY PROTEIN GENE | 2014 |
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| MICE WITH HUMANIZED LIGHT CHAIN | 2012 |
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| HUMANIZED MODEL OF KIDNEY AND LIVER DISORDERS | 2018 |
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| GENETICALLY MODIFIED NON-HUMAN ANIMALS EXPRESSING HUMAN EPO | 2015 |
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RU2799086C2 |
| ANIMALS OTHER THAN HUMANS HAVING A HUMANISED CLUSTER GENE OF DIFFERENTIATION 47 | 2015 |
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RU2728412C2 |
