FIELD: biotechnology.
SUBSTANCE: invention relates to an isolated rodent motor neuron, where the genome of the isolated rodent motor neuron contains a deletion from the coding portion of exon 2 to the coding portion of exon 11 of the endogenous locus C9orf72, as well as to a method for preparing said motor neuron.
EFFECT: invention is effective for screening a candidate agent for reducing mitochondrial dysfunction and/or oxidative stress in a motor neuron of a tested rodent.
14 cl, 10 dwg, 6 tbl, 4 ex
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