METHOD AND DEVICE FOR NON-INVASIVE OPTICAL IN VIVO DETERMINATION OF GLUCOSE CONCENTRATION IN LEAKING BLOOD Russian patent published in 2020 - IPC A61B5/1477 A61B8/00 G01J5/58 

FIELD: medicine; endocrinology.

SUBSTANCE: group of inventions can be used for non-invasive in vivo determination of glucose concentration in leaking blood in a blood vessel inside the body. Body is irradiated with ultrasonic radiation with an ultrasonic frequency for marking of a blood vessel. Body with a blood vessel is irradiated with radiation having at least a first wavelength at which intensity of back scattered radiation depends on concentration of glucose. Body with a blood vessel is exposed to radiation having a second wavelength corresponding to a water absorption line whose position depends on the blood temperature. Back-scattered radiation is detected using at least one sensor. Corresponding signal components, modulated with ultrasonic frequency-dependent modulation frequency, are extracted using a computing unit from signals, produced by sensor. Values for glucose concentration are determined using a signal component identified on said at least a first wavelength. Value of index is corrected by means of signal component of second radiation wavelength to compensate for dependence on temperature, wherein without measurement of absolute temperature and without preliminary temperature calibration. Device for non-invasive optical in vivo detection of blood glucose concentration in blood in a blood vessel inside a body comprises an ultrasound source, a first laser radiation source for generating radiation with a first wavelength, a second laser radiation source for generating radiation with a second wavelength, an optical sensor for detecting back scattered radiation, a control and calculation unit which is connected to an ultrasound source, laser radiation sources and a sensor. Computing unit is configured to be used to extract corresponding signal components, modulated with modulation frequency, which depends on ultrasound frequency (fUS), from sensor signals, measured by sensor. Glucose concentration value is determined using a signal component identified at the first wavelength. Value of the index is corrected using a signal component with a second emission wavelength to compensate for temperature dependence. Without measurement of absolute temperature and without preliminary temperature calibration.

EFFECT: method and apparatus provide simplification and improvement of non-invasive optical in vivo determination of glucose concentration in a blood stream in a blood vessel inside a body by combining several measurements with at least two, preferably at least three, radiation wavelengths.

18 cl, 3 dwg