METHOD OF PREPARING 3A-AROYL-2-ISOPROPYL-3-(ISOPROPYLIMINO)-3,3A-DIHYDROBENZO[d]PYRROLO[3',4':2,3]PYRROLO[2,1-b]THIAZOLE-1,4,5(2H)-TRIONES EXHIBITING ANTIOXIDANT ACTIVITY Russian patent published in 2023 - IPC C07D513/14 A61K31/429 A61P39/06 

Abstract RU 2810075 C1

FIELD: pharmacology.

SUBSTANCE: invention relates to a method of production of 3a-aroyl-2-isopropyl-3-(isopropylimino)-3,3a-dihydrobenzo[d]pyrrolo[3',4':2,3]pyrrolo[2,1-b]thiazole-1,4,5(2H)-triones exhibiting antioxidant activity, which can be used as starting products for the synthesis of new heterocyclic systems and in pharmacology. The method involves the interaction of 3-aroylpyrrolo[2,1-c][1,4]benzothiazine-1,2,4-triones with diisopropylcarbodiimide in anhydrous toluene when heated at 110°C for 1.5 hours, followed by the release of products (IIIa-c).

EFFECT: development of a simple method of the synthesis of 3a-aroyl-2-isopropyl-3-(isopropylimino)-3,3a-dihydrobenzo[d]pyrrolo[3',4' :2,3]pyrrolo[2,1-b]thiazole-1,4,5(2H)-triones.

1 cl, 2 tbl, 5 ex

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RU 2 810 075 C1

Authors

Maslivets Andrei Nikolaevich

Khramtsova Ekaterina Evgenevna

Lystsova Ekaterina Aleksandrovna

Dates

2023-12-21Published

2023-03-16Filed