FIELD: pharmacology.
SUBSTANCE: invention relates to a method of production of 3a-aroyl-2-isopropyl-3-(isopropylimino)-3,3a-dihydrobenzo[d]pyrrolo[3',4':2,3]pyrrolo[2,1-b]thiazole-1,4,5(2H)-triones exhibiting antioxidant activity, which can be used as starting products for the synthesis of new heterocyclic systems and in pharmacology. The method involves the interaction of 3-aroylpyrrolo[2,1-c][1,4]benzothiazine-1,2,4-triones with diisopropylcarbodiimide in anhydrous toluene when heated at 110°C for 1.5 hours, followed by the release of products (IIIa-c).
EFFECT: development of a simple method of the synthesis of 3a-aroyl-2-isopropyl-3-(isopropylimino)-3,3a-dihydrobenzo[d]pyrrolo[3',4' :2,3]pyrrolo[2,1-b]thiazole-1,4,5(2H)-triones.
1 cl, 2 tbl, 5 ex
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