CONDENSED TRICYCLIC COMPOUND AS DOUBLE INHIBITOR OF PDE3/PDE4 Russian patent published in 2024 - IPC C07D471/04 C07D487/04 C07D498/04 A61K31/517 A61K31/519 A61K31/55 A61K31/553 A61P11/00 A61P11/08 

FIELD: chemistry.

SUBSTANCE: group of inventions relates to organic chemistry and includes a condensed tricyclic compound of formula (I), a stereoisomer, a tautomer, a pharmaceutically acceptable salt, a pharmaceutical composition containing it, use and a method of treatment. In formula (I), ring Cy is selected from a group consisting of 5-membered heterocyclyl containing 1–3 heteroatoms selected from a group consisting of N, O and S, and 5-member heteroaryl containing at least one ring atom selected from the group consisting of N, O and S, where 5-member heterocyclyl or 5-member heteroaryl is optionally substituted with one or more of the following groups: amino, hydroxy, =O, halogen, cyano, C_1-6alkyl, -C(O)NH₂, -C(O)NH(C_1-3alkyl), -C(O)N(C_1-3alkyl)₂, -C(O)O(C_1-3alkyl) or C_1-6alkoxy, where C_1-6alkyl is optionally substituted with one or more groups selected from the group consisting of halogens, amino and hydroxy; ring atoms in the Cy ring include at least one nitrogen atom; L is selected from a group consisting of -N(R⁶)-, -N(R⁶)C(O)-, -C(O)N(R⁶)-, -O-, -S-, -CH₂N(R⁶)C(O)-, -CH₂C(O)N(R⁶)-, -S(O)₂NH-, -NHS(O)₂- and single bond; n is equal to 1, 2, 3 or 4; E¹ is -(CH₂)_m-, where m is equal to 1, 2 or 3; E² is selected from a group consisting of -O-, -NH-, -S- and a single bond; each of R³, R⁴ and R⁵ is independently selected from the group consisting of hydrogen, halogen and C_1-6alkyl; each R⁶ is independently selected from the group consisting of hydrogen and hydroxy.

EFFECT: compound of formula (I) as a dual inhibitor of PDE3/PDE4.

55 cl, 2 dwg, 5 tbl, 71 ex