METHOD OF CORRECTION OF REPERFUSION ISCHEMIC INJURY IN PARTIAL NEPHRECTOMY FOR LOCALIZED CANCER IN CONDITIONS OF THERMAL ISCHEMIA Russian patent published in 2020 - IPC G01N33/48 A61K35/16 A61K47/42 

FIELD: medicine.

SUBSTANCE: invention refers to medicine, particularly to oncology, namely correction of reperfusion ischemic injury accompanying kidney resection for localized cancer in conditions of thermal ischemia. That is ensured by determining a pre-surgical blood serum concentration of cystatin C - denoted by Z, as well as concentration of L-FABP and NGAL, the duration of thermal kidney ischemia - TKI, is marked intraoperatively, symbolized Y, 16 hours after the operation, patient's diuresis is diagnosed - symbolized by a, concentration of cystatin C - is denoted by a symbol b, concentration of NGAL - denoted by a symbol c and L-FABP - is denoted by a symbol d in venous blood, symbol X denotes sum of products a, b, c and d by corresponding weight coefficients, then for each of indicators X, Y, Z calculating conditional numerical value in points from 0 to 1, then by formula α = X + Y + Z total score is calculated. With value α < 3 in the patient does not have a risk of developing acute renal damage and therefore does not require additional therapy, with value α = 3 infusion nephroprotective therapy aimed at correction of circulating blood volume, anaemia, protein-energy deficiency, water-electrolyte and acid-base balance, as well as antioxidant therapy.

EFFECT: invention enables timely diagnosing the developing complication in the form of acute renal damage in the patients following kidney resection for localized renal cell carcinoma in the conditions of total TKI, well-timed pathogenetic therapy associated with the acute kidney injury and significantly reducing the period of hospitalization and rehabilitation.

1 cl, 3 ex