FIELD: physics.
SUBSTANCE: invention relates to a method for filtration of protein-containing liquid. Method of filtration of liquid containing protein in concentration from 20 mg/ml to 100 mg/ml, including: stage of preliminary filtration of protein containing liquid by means of preliminary filter, having pore size of 0.08 mcm - 0.25 mcm and containing hydrophobic resin, and a step for removing viruses after the pre-filtration step by filtering the protein-containing liquid with a virus removal membrane comprising a synthetic polymer, wherein the protein containing liquid before the pre-filtration step contains 0.25 g or more of a trimer or a multimer of proteins having an average diameter less than 100 nm per 1 m2 of the virus removal membrane.
EFFECT: technical result is higher efficiency of reducing the number of viruses without denaturation of useful proteins.
25 cl, 13 ex, 14 dwg
| Title |
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