FIELD: chemistry.
SUBSTANCE: invention relates to a method of producing (R)-5-(3,4-difluorophenyl)-5-[(3-methyl-2-oxopyridine-1(2H)-yl)methyl]imidazolidine-2,4-dione
including: (a) a step for separating an isomer represented by following formula (2)
from a mixture of isomers of formula (1); and
(b) a step for removing the mentyloxycarbonyl group of the compound, represented by formula (2) recovered at step (a), to obtain (R)-5-(3,4-difluorophenyl)-5-[(3-methyl-2-oxopyridine-1(2H)-yl)methyl]imidazolidine-2,4-dione.
EFFECT: invention discloses a method of producing (R)-5-(3,4-difluorophenyl)-5-[(3-methyl-2-oxopyridine-1(2H)-yl)methyl]imidazolidine-2,4-dione and an intermediate compound for obtaining.
3 cl, 2 dwg, 1 tbl, 4 ex
Title | Year | Author | Number |
---|---|---|---|
(+)-5-(3,4-DIFLUOROPHENYL)-5-[(3-METHYL-2-OXOPYRIDIN-1(2H)-YL)METHYL]IMIDAZOLIDINE-2,4-DIONE AND DRUG CONTAINING SAME | 2014 |
|
RU2668072C2 |
5-[(PIPERAZIN-1-YL)-3-OXO-PROPYL]-IMIDAZOLIDINE-2,4-DIONE DERIVATIVES AS ADAMTS INHIBITORS FOR TREATING OSTEOARTHRITIS | 2015 |
|
RU2693459C2 |
METHODS FOR SYNTHESIS OF 3-(4-(2,4-DIFLUOROBENZYLOXY)-3-BROMO-6-METHYL-2-OXOPYRIDIN-1 (2H)-YL)-N-4-DIMETHYLBENZAMIDE | 2007 |
|
RU2411236C1 |
NEW DERIVATIVES OF HYDANTOIN AS INHIBITORS OF METAL PROTEINASES | 2005 |
|
RU2376301C2 |
DERIVATIVES OF QUINOLINE XANTHINE AND 8-ISOQUINOLINE XANTHINE AS INHIBITORS OF PHOSPHODIESTERASE PDE-5 | 2001 |
|
RU2269529C2 |
NOVEL HYDANTOIN DERIVATIVES AS METALLOPROTEINASE INHIBITORS | 2005 |
|
RU2378269C2 |
SUBSTITUTED 3,4,12,12A-TETRAHYDRO-1H-[1,4]OXAZINO[3,4-C]PYRIDO[2,1-F][1,2,4]TRIAZINE-6,8-DIONE, PHARMACEUTICAL COMPOSITION, METHODS FOR PRODUCTION AND USE THEREOF | 2019 |
|
RU2720305C1 |
COMPOUNDS INHIBITING (BLOCKING) BITTER TASTE, METHODS FOR USE AND PRODUCTION THEREOF | 2008 |
|
RU2522456C2 |
NOVEL HETEROCYCLIC COMPOUNDS AND USE THEREOF IN MEDICINE AND COSMETICS | 2015 |
|
RU2712971C2 |
DERIVATIVES OF 3-(5-TETRAZOLYLBENZYL)-AMINOPIPERIDINE, METHODS OF THEIR SYNTHESIS AND PHARMACEUTICAL COMPOSITION ON SAID | 1994 |
|
RU2136675C1 |
Authors
Dates
2020-11-05—Published
2017-09-21—Filed