FIELD: medicine.
SUBSTANCE: group of inventions can be used for preparing the high bioavailability of the oromucosal pharmaceutical compositions. Disclosed is a composite obtained by complexing API in hydroxypropyl-β-cyclodextrin, carried out in the presence of sucralose, where composite has molar ratio HPβCD: sucralose from 1:0.05 to 1:0.8 and API is a steroid, as well as a composite on an aqueous carrier. Also disclosed are a method of producing a composite and a pharmaceutical composition for the oromucosal administration containing it; using the composition or composite for treating a disease characterized by reduced production of a steroid.
EFFECT: group of inventions increases bioavailability of API due to selective mixing of sucralose with steroid active principles in combination with HPβCD.
16 cl, 2 dwg, 8 tbl, 11 ex
| Title |
Year |
Author |
Number |
| AQUEOUS ORAL SOLUTIONS OF STEROID HORMONES AND HYDROXYPROPYL-BETA-CYCLODEXTRIN WITH OPTIMISED BIOAVAILABILITY |
2013 |
- Bernaredzhi Alberto
- Puppini Nadiya
- Nenchioni Alessandro
|
RU2662314C2 |
| METHOD OF PREPARING THE COMPLEX OF SILIBININE WITH CYCLODEXTRIN, INCLUSION COMPLEX OF SILIBININE WITH CYCLODEXTRIN, PHARMACEUTICAL COMPOSITION SHOWING ANTIHEPATOTOXIC ACTIVITY AND A METHOD OF ITS PREPARING |
1991 |
- Umberto Valkavi[It]
- Vintsentso Monterosso[It]
- Roberto Kaponi[It]
- Ehnriko Bozone[It]
- Vil'Frid Peter Vakhter[De]
- Jozhef Sejtli[Hu]
|
RU2108109C1 |
| METHOD FOR OBTAINING AMORPHOUS CO-EVAPORATES OF CLADRIBIN WITH CYCLODEXTRINS |
2021 |
- Babij Vladimir Evstakhievich
- Konoplyannikov Ivan Georgievich
- Zabudkin Oleksandr
- Mata Vladimir
|
RU2758436C1 |
| DOSAGE FORM FOR RELEASING DROTAVERINE IN ORAL CAVITY |
2019 |
- Fonarev Mikhail Yurevich
- Ezhova Ekaterina Aleksandrovna
- Zakalyukina Evgeniya Viktorovna
- Ivanova Alena Andreevna
|
RU2729659C1 |
| DOSAGE FORM FOR SUPPRESSING BACTERIAL INFECTIONS, METHOD OF ITS ORGANIZATION |
2023 |
- Drannikov Aleksandr Alekseevich
|
RU2813197C1 |
| COMPLEX OF RAS-FARNESYLTRANSFERASE INHIBITOR, COMPOSITION OF RAS-FARNESYLT RANSFERASE INHIBITOR, PHARMACEUTICAL COMPOSITION |
1999 |
- Radzhkhavan Krishnasvami S.
- Mehlloi Timoti M.
- Vehria Sehjlesh A.
|
RU2230062C2 |
| COMPOSITIONS CONTAINING POLYSACCHARIDE MATRIX FOR CONTROLLED RELEASE OF ACTIVE INGREDIENTS |
2017 |
- Morpurgo, Margarita
- Byankini, Dzhulio
- Kallegaro, Lanfranko
|
RU2748261C2 |
| METHOD FOR PREPARING PHARMACEUTICAL COMPOSITION ELICITING ANTI-INFLAMMATORY AND ANALGETIC ACTIVITY AND COMPRISING AMORPHOUS NITROESTERS |
2000 |
- Benedini Francheska
- Antognatstsa Patritsija
|
RU2248963C2 |
| ANTIBACTERIAL COMPOSITION OF GRAMICIDIN C, A METHOD OF ITS PRODUCTION AND USE |
2022 |
- Balabanyan Vadim Yurevich
- Fazylov Marat Feliksovich
|
RU2800287C1 |
| NANOPARTICLES CONTAINING CYCLODEXTRIN AND BIOLOGICALLY ACTIVE MOLECULE, AND USING THEM |
2008 |
- Aguehros Baso Majte
- Sal'Man Khesham Kh.A.
- Irache Garreta Khuan Manuehl'
- Kampanero Martines Migel' Ankhel'
|
RU2460518C2 |
