NOVEL 2,4,6-TRISUBSTITUTED S-TRIAZINE COMPOUND, A METHOD FOR PRODUCTION THEREOF AND USE THEREOF Russian patent published in 2020 - IPC C07D251/18 C07D401/12 C07D403/04 C07D403/12 A61K31/53 A61K31/5377 A61P9/00 A61P9/10 A61P31/00 A61P35/00 A61P35/02 

FIELD: medicine; pharmaceuticals.

SUBSTANCE: invention relates to a compound of general formula I, or pharmaceutically acceptable salts thereof, or solvates thereof, in which R₁ denotes hydrogen, halogen or nitro; R₂ is -NR₄R₅, where R₄ and R₅ are independently selected from a group consisting of C₁-C₆alkyl; or R₄, R₅ and the nitrogen atom to which they are bonded form saturated 4–6-member heterocyclic ring containing optionally an additional heteroatom, selected from a group consisting of NR₆ and O, where the heterocyclic ring is optionally substituted with hydroxyl or C₁-C₆alkyl, where R₆ is C₁-C₆alkyl; R₃ denotes halogen, C₁-C₆alkoxy or -COR_a; R_a is OH or NR₇R₈, where R₇ and R₈ are independently selected from a group consisting of hydrogen, C₁-C₆alkyl optionally substituted with one or more substitutes selected from halogen or NR₉R₁₀, and C₁-C₆alkyl substituted with 3-(C₂-C₆alkynyl)-3H-diaziridinyl; or R₇, R₈ and the nitrogen atom to which they are bonded, form 6-member heterocyclic ring containing optionally an additional heteroatom which is N, and optionally substituted with C₁-C₆alkyl; R₉ and R₁₀ are independently selected from a group consisting of C₁-C₆alkyl; or R₉, R₁₀ and the nitrogen atom to which they are bonded, form 5–6 membered heterocyclic ring, containing optionally additional heteroatom, which is O; and X is NH or O attached to the phenyl group by a para- or meta-position. Invention also relates to a pharmaceutical composition, to the use of the compound in the manufacture of a medicinal agent.

EFFECT: obtaining novel compounds of general formula I, which can be used in treating a vimentin mediated disease.

12 cl, 7 dwg, 6 tbl, 9 ex