FIELD: biotechnology.
SUBSTANCE: invention relates to biotechnology and can be used in medicine for preventing and/or treating a subject with a BORIS-expressing tumour. Disclosed are nucleic acid molecules containing one or more nucleic acid sequences encoding the synthetic consensus antigen BORIS. Disclosed are a vector, a vaccine, containing one or more nucleic acid sequences encoding the synthetic consensus antigen BORIS. Disclosed are a method for treating a subject with a BORIS-expressing tumour and a method for vaccinating a subject against one expressing an antigen - Brother of the Regulator of an Imprinted Site (BORIS) of the cancer cell. Disclosed is the synthetic consensus antigen BORIS.
EFFECT: invention proposes a safe and effective vaccine and methods for application thereof for preventing and/or treating cancer and reducing the mortality in subjects suffering from cancer.
17 cl, 16 dwg, 8 tbl, 3 ex
| Title |
Year |
Author |
Number |
| ANTICANCER VACCINES TARGETING BORIS AND METHODS OF THEIR APPLICATION |
2018 |
- Yan, Jian
- Slager, Anna
- Garman, Bradley
- Cooch, Neil
|
RU2759681C1 |
| SURVIVIN-TARGETED ANTI-CANCER VACCINES AND APPLICATIONS THEREOF |
2018 |
- Yan, Jian
- Slager, Anna
- Garman, Bradley
- Cooch, Neil
|
RU2776949C2 |
| ANTI-CANCER VACCINES TARGETED WITH SURVIVIN AND THEIR APPLICATION |
2018 |
- Yan, Jian
- Slager, Anna
- Garman, Bradley
- Cooch, Neil
|
RU2751253C1 |
| MUC16-TARGETING ANTICANCER VACCINES AND APPLICATION THEREOF |
2018 |
- Yan, Jian
- Slager, Anna
- Garman, Bradley
- Cooch, Neil
|
RU2777918C2 |
| ANTI-CANCER VACCINES TARGETING MUC16 AND THEIR USE |
2018 |
- Yan, Jian
- Slager, Anna
- Garman, Bradley
- Cooch, Neil
|
RU2750689C1 |
| ANTI-CANCER VACCINES AIMED AT LEMD1 AND THEIR USE |
2018 |
- Yan, Jian
- Slager, Anna
- Garman, Bradley
- Cooch, Neil
|
RU2760984C1 |
| ANTI-CANCER VACCINES TARGETING PRAME AND THEIR APPLICATIONS |
2018 |
- Yan, Jian
- Slager, Anna
- Garman, Bradley
- Cooch, Neil
|
RU2748903C1 |
| MESOTHELINE-TARGETED CANCER VACCINES AND THEIR APPLICATION |
2018 |
- Yan, Jian
- Slager, Anna
- Garman, Bradley
- Cooch, Neil
|
RU2751252C1 |
| CHIMERIC PROTEIN, A SYNTHETIC DNA WHICH CODES SAID PROTEIN, AN EXPRESSION VECTOR, A SYNTHETIC DNA PRODUCING STRAIN AND A METHOD OF PRODUCING PLASMID DNA |
2016 |
- Dukhovlinov Ilya Vladimirovich
|
RU2736472C2 |
| VIRUS-ENCODED REGULATED AGENTS BINDING T-CELLS (CATVERT) OR NK-CELLS (CATVERN) TARGETING CANCER |
2020 |
- Cripe, Timothy, P.
- Chen, Chun-Yu
- Hutzen, Brian
- Currier, Mark
- Wang, Pin-Yi
- Chandler, Dawn
|
RU2827779C2 |
