FIELD: biotechnology.
SUBSTANCE: invention relates to biotechnology. Disclosed herein are nucleic acid molecules containing one or more nucleic acid sequences that encode synthetic consensus survivin antigens. Disclosed are vectors, compositions and vaccines containing one or more nucleic acid sequences that encode synthetic consensus survivin antigens. Disclosed are methods for treating a subject with survivin-expressing tumor and methods of preventing survivin-expressing tumor. The synthetic consensus antigens of survivin are disclosed.
EFFECT: invention makes it possible to obtain safe and effective vaccines for prevention and / or treatment of cancer and reduction of mortality of individuals suffering from cancer, which expresses survivin.
23 cl, 32 dwg, 14 tbl, 5 ex
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