FIELD: pharmaceuticals; medicine.
SUBSTANCE: objects 1 and 2 are an RNA delivery composition containing RNA lipoplex particles comprising RNA and 1,2-di-O-octadecenyl-3-trimethylammoniumpropane (DOTMA) and 1,2-di-(9Z-octadecenoyl)-sn -glycero-3-phosphoethanolamine (DOPE), sodium chloride, stabilizer and buffer. Objects 3 and 4 are a liquid composition for RNA delivery containing RNA lipoplex particles, obtained by thawing a frozen composition or dissolving a dehydrated composition. Objects 5 and 6 are a method of preparing a liquid composition containing RNA lipoplex particles for direct administration to a subject, including thawing a frozen composition or dissolving a dehydrated composition.
EFFECT: stability of the composition when stored for a long period of time and the ability to be administered parenterally.
35 cl, 71 dwg, 10 tbl, 28 ex
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