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2 738 863

(13)

(51)

IPC

G01N33/53(2006-01-01)

(21) (22)

Application

2020113866, 2020-04-03

(24)

Start date

2020-04-03

(22)

Actual filing date

2020-04-03

(45)

Published

2020-12-17

(72)

Inventor

Dyakonov Dmitrij AndreevichMinaev Maksim SergeevichPerfilova Elena Aleksandrovna

(73)

Holder

Federalnoe Gosudarstvennoe Byudzhetnoe Uchrezhdenie Nauki Nauchno-Issledovatelskij Institut Gematologii I Perelivaniya Krovi Federalnogo Mediko-Biologicheskogo Agentstva"

METHOD FOR MORPHOMETRIC ESTIMATION OF PREDICTION OF CLINICAL COURSE OF NODULAR SCLEROSIS OF HODGKIN LYMPHOMA BY A PERCENTAGE SCORE CD163+ AND CD68+ MACROPHAGES IN LYMPH NODES Russian patent published in 2020 - IPC G01N33/53

Abstract RU 2738863 C1

FIELD: medicine.

SUBSTANCE: invention refers to medicine, particularly to hematology, and aims at predicting the course of nodular sclerosis of Hodgkin lymphoma (HL). After lymphadenectomy in histological sections of lymphoid organ, immunohistochemical staining is carried out and relative quantity of CD163+ and CD68+ macrophages in lymph nodes is calculated morphometrically by formulas S₁=D₁/n×100% and S₂=D₂/n×100%. Percentage score PS of these cells is determined by formula PS=(S₁+S₂)/2. If the PS values are less than or equal to 12.0%, the favorable course of nodular sclerosis HL is stated, and if more than 12.0% the unfavorable course of the disease is stated.

EFFECT: invention provides effective prediction of clinical course of nodular sclerosis HL after lymphadenectomy.

1 cl, 2 ex

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RU 2 738 863 C1

Authors

Dyakonov Dmitrij Andreevich

Minaev Maksim Sergeevich

Perfilova Elena Aleksandrovna

Dates

2020-12-17—Published

2020-04-03—Filed