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2 828 024

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IPC

G01N33/53(2006-01-01)

(21) (22)

Application

2023120500, 2023-08-04

(24)

Start date

2023-08-04

(22)

Actual filing date

2023-08-04

(45)

Published

2024-10-07

(72)

Inventor

Dyakonov Dmitrij AndreevichMinaev Maksim SergeevichPerfilova Elena Aleksandrovna

(73)

Holder

Federalnoe Gosudarstvennoe Byudzhetnoe Uchrezhdenie Nauki Nauchno-Issledovatelskij Institut Gematologii I Perelivaniya Krovi Federalnogo Mediko-Biologicheskogo Agentstva" Kniigipk Fmba Rossii)

METHOD FOR PREDICTING CLINICAL COURSE OF NODULAR SCLEROSIS HODGKIN'S LYMPHOMA BY MORPHOMETRIC EVALUATION OF INDEX OF PROPORTION OF POSITIVE TUMOUR CELLS PD-L1 TO BCL2 IN LYMPH NODES Russian patent published in 2024 - IPC G01N33/53

Abstract RU 2828024 C1

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely to haematology and pathological anatomy, and can be used for prediction of the clinical course of nodular sclerosis of Hodgkin's lymphoma. That is ensured by immunohistochemical staining after lymphadenectomy. Relative number of PD-L1- and BCL2-positive tumour cells is calculated using the developed mathematical formulas. Further, the index of the ID fraction is determined using a mathematical formula. If the ID is less than or equal to 73%, a favourable clinical course is predicted. If the ID is more than 73%, the unfavourable clinical course of the disease is predicted.

EFFECT: invention allows predicting the clinical course of lymphoma of Hodgkin's lymphoma in patients after lymphadenectomy.

1 cl, 2 ex

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RU 2 828 024 C1

Authors

Dyakonov Dmitrij Andreevich

Minaev Maksim Sergeevich

Perfilova Elena Aleksandrovna

Dates

2024-10-07—Published

2023-08-04—Filed