FIELD: medicine.
SUBSTANCE: invention relates to obstetrics, and can be used to predict the recurrence of early preeclampsia by markers of endothelial dysfunction. The level of endothelin-1 and the level of microvesicles (EVs) of endothelial origin 0.1–1 μm in size are determined in blood plasma at gestation periods of 11–13 weeks using antibodies to CD144. The risk of developing early preeclampsia is predicted at an endothelin-1 level of more than 0.497 pmol/ml and an EVs level of endothelial origin of more than 0.97 CD144+ events/µl.
EFFECT: method provides the possibility of predicting the recurrence of early preeclampsia in patients at risk, allowing timely stratification of pregnant women into a group for additional examination methods and preventive measures, by determining the concentration of endothelin-1 in peripheral blood plasma and measuring the number of CD144 positive (+) events (EVs of endothelial origin) in the volume of platelet-free blood plasma during 11–13 weeks of gestation.
1 cl, 4 dwg, 2 ex
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