PEPTIDE COMPOSITION Russian patent published in 2021 - IPC A61K47/42 A61K9/08 A61L27/00 

FIELD: medicine.

SUBSTANCE: group of inventions relates to a stable peptide composition comprising: a self-assembling peptide; buffer agent containing at least one substance selected from a group, consisting of histidine, thiamine nitrate, pyridine, bis-tris, ethylenediamine and/or N-methylmorpholine; and water, wherein stable peptide composition has pH from 4.5 to 6.6; wherein the total charge of the amino acid residues contained in the self-assembling peptide is between more than 0 and +3 or less in the stable peptide composition; wherein the C-terminal of the self-assembling peptide includes an amide group; wherein the amino acid at the C-terminal of the self-assembling peptide contains a basic amino acid; wherein the self-assembling peptide is formed from the following amino acid sequence: a₁b₁c₁b₂a₂b₃db₄a₃b₅c₂b₆a₄, where each residue a₁–a₄ is a basic amino acid residue, each residue b₁–b₆ is an uncharged polar amino acid residue and/or a hydrophobic amino acid residue, provided that at least five of them are a hydrophobic amino acid residue, each residue c₁–c₂ is an acidic amino acid residue and d is a hydrophobic amino acid residue; wherein the self-assembling peptide contains a peptide formed by the amino acid sequence: n-RLDLRLALRLDLR-c (SEQ ID NO:1), n-RLDLRLSLRLDLR-c (SEQ ID NO:2), n-RLALRLDLRLDLR-c (SEQ ID NO:3), n-KRLDLNLRLDLRK-c (SEQ ID NO:4), and also relates to a method of producing a stable peptide composition.

EFFECT: group of inventions provides a stable and transparent peptide composition.

4 cl, 4 tbl, 14 ex