FIELD: medicine.
SUBSTANCE: invention refers to medicine, namely to experimental biology and toxicology, and can be used to simulate chronic alcohol intoxication in experimental rats. For this purpose experimental animals are daily introduced for 30 days with 40% ethanol solution in dose of 3 g/kg simultaneously with daily introduction of isovaleric acid amide solution into stomach in dose of 500 mg/kg of animal's weight, where per unit of solution equal to 0.9 ml, there is 50 mg of isovaleric acid amide.
EFFECT: method provides higher reproducibility of developing chronic intoxication in a shorter period of time.
1 cl, 2 tbl, 1 ex, 2 dwg
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD FOR MODELING ALCOHOL-INDUCED NEPHROPATHY AGAINST THE BACKGROUND OF AUTOIMMUNE NEPHRITIS IN RATS IN AN EXPERIMENT | 2021 |
|
RU2771258C1 |
| METHOD FOR THE PREVENTION OF ALCOHOL-INDUCED NEPHROPATHY ON THE BACKGROUND OF LEAD INTOXICATION IN RATS IN THE EXPERIMENT | 2022 |
|
RU2786469C1 |
| METHOD FOR SIMULATING CHRONIC TOXIC NEPHROPATHY IN RATS IN EXPERIMENT | 2020 |
|
RU2743843C1 |
| METHOD FOR PREVENTION OF NEPHROTOXIC EFFECT OF MOLYBDENUM | 2020 |
|
RU2786641C2 |
| METHOD FOR PREVENTION OF NEPHROTOXIC ACTION OF ANTIMONY IN RATS IN EXPERIMENT | 2023 |
|
RU2815874C1 |
| METHOD FOR MODELING OF CHRONIC TOXIC NEPHROPATHY IN EXPERIMENTAL ANIMALS | 2022 |
|
RU2793544C1 |
| METHOD FOR PREVENTION OF NEPHROTOXIC ACTION OF CHROMIUM IN RATS IN EXPERIMENT | 2022 |
|
RU2793548C1 |
| METHOD OF REDUCING NEPHROTOXICITY OF AMMONIUM MOLYBDATE | 2015 |
|
RU2588319C1 |
| METHOD FOR PREVENTION OF TOXIC ACTION OF COBALT IN EXPERIMENTAL ANIMALS SUFFERING CHRONIC POISONING | 2010 |
|
RU2431482C1 |
| METHOD OF MODELING CHRONIC TOXIC COAGULOPATHY IN RATS | 2023 |
|
RU2800860C1 |
