FIELD: chemistry.
SUBSTANCE: present invention relates to use of 2-(6,8-dimethyl-5-nitro-4-chloroquinolin-2-yl)-5,6,7-trichloro-1,3-tropolone of formula 1
as agent possessing cytotoxic activity on non-small-cell lung cancer A 549 culture.
EFFECT: organic compound of formula 1 enables to inhibit the growth of lung tumor cells in a lower concentration compared to concentrations of compounds known in this series, having cytotoxic activity.
1 cl, 1 ex
| Title | Year | Author | Number |
|---|---|---|---|
| 2-(1,1-DIMETHYL-1H-BENZO[E]INDOLIN-2-YL)-5,6,7-TRICHLORO-1,3-TROPOLONE, WHICH HAS CYTOTOXIC ACTIVITY AGAINST A431 SKIN CANCER AND H1299 LUNG CANCER CELL CULTURES | 2023 |
|
RU2810581C1 |
| 5,7-DI(TERT-BUTYL)-2-(4,7-DICHLORO-8-METHYL-5-NITROQUINOLIN-2-YL)-4-NITRO-1,3-TROPOLONE, HAVING CYTOTOXIC ACTIVITY | 2019 |
|
RU2702648C1 |
| SODIUM COBALT POLYGALACTURONATE WITH ANTITUMOR ACTIVITY | 2023 |
|
RU2794885C1 |
| ANTITUMOR AGENTS BASED ON MACRO- AND MICROELEMENT-CONTAINING POLYGALACTURONATES (OPTIONS) | 2022 |
|
RU2792613C1 |
| NEW STERICALLY HINDERED PHENOLS CONTAINING BENZOFUROXAN FRAGMENTS WITH ANTITUMOR ACTIVITY | 2022 |
|
RU2796810C1 |
| N-(2-(2-(2-AZIDOETHOXY)ETHOXY)ETHYL)-4,6-DI(AZIRIDIN-1-YL)-1,3,5-TRIAZIN-2-AMINE, HAVING CYTOTOXIC ACTION | 2023 |
|
RU2825828C1 |
| BROMINE-CONTAINING STERICALLY HINDERED PHENOLS WITH ANTICANCER ACTIVITY | 2023 |
|
RU2822270C1 |
| METHYL 6-[(4-(AZIRIDIN-1-YL)-6-CHLORO-1,3,5-TRIAZIN-2-YL)AMINO]HEXANOATE, WHICH HAS A CYTOTOXIC EFFECT | 2022 |
|
RU2791798C1 |
| HUMAN BREAST CANCER CELL LINE BrCCh4e | 2019 |
|
RU2717654C1 |
| MIXED-LIGAND COMPLEXES OF COPPER (II) WITH 1H-TETRAZOLE-5-ACETIC ACID AND OLIGOPYRIDINE DERIVATIVES, EXHIBITING CYTOTOXIC ACTIVITY | 2023 |
|
RU2818953C1 |
