FIELD: molecular biology; biochemistry; biotechnology.
SUBSTANCE: invention represents an agent which is (4E)-10-{2-[(E)-2-[(4-bromophenyl)methylidene]hydrazin-1-yl]-1,3-thiazol-4-yl}-4-(1-{[3-(3,5-di-tert-butyl-4-hydroxyphenyl)propyl]amino}ethylidene)-11,13-dihydroxy-2,12-dimethyl-8-oxatricyclo[7.4.0.02,7]trideca-1(13),6,9,11-tetraene-3,5-dione of formula I, having the ability to enhance cytotoxic, anticancer and antimetastatic action of topotecan..
EFFECT: inhibitor of the Tdp1 repair enzyme of formula I, exhibiting the ability to enhance the cytotoxic, anticancer and antimetastatic action of topotecan.
1 cl, 8 dwg, 1 tbl, 5 ex
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