METHOD OF DIFFERENTIAL DIAGNOSIS OF GLIAL BRAIN TUMORS Russian patent published in 2021 - IPC G01N33/574 G01N33/58 

FIELD: molecular biology and medicine.

SUBSTANCE: invention relates to the field of molecular biology and medicine and namely to oncology and neurosurgery. The invention is intended for the differential diagnosis of glial brain tumors. A brain tissue sample is taken, RNA is isolated, and gene expression is determined by real-time RT-PCR. The expression of the TIE2 and MELK genes is measured. The conclusion about the presence and a type of glial brain tumor is based on the values ​​of the MELK/TIE2 gene expression index. If the MELK/TIE2 gene expression index is more than 400, a glioblastoma is diagnosed. If the MELK/TIE2 gene expression index is less than 400 but more than 1.8, a grade III glioma is diagnosed. If the MELK/TIE2 expression index is less than 1.8, the disease is not associated with a malignant tumor.

EFFECT: invention simplifies the method of differential diagnosis of malignant brain tumors and reduces its labor intensity.

1 cl, 1 dwg, 3 ex