DERIVATIVES OF 3-(6-CHLORO-3-OXO-3.4-DIHYDRO-(2H)-1.4-BENZOXASIN-4-YL)PROPIONIC ACID AND THEIR USE AS KMO INHIBITORS Russian patent published in 2021 - IPC C07D413/12 A61K31/538 A61P1/16 A61P1/18 A61P13/12 A61P25/00 A61P29/00 A61P31/00 A61P11/00 

FIELD: medicine.

SUBSTANCE: invention relates to new compounds of formula (I), pharmaceutical compositions made on their basis, the use and method of treating a condition or disorder mediated by CMO.

EFFECT: new compounds that are CMO inhibitors and may be useful for the treatment of disorders mediated by CMO like acute pancreatitis, chronic kidney disease, other conditions associated with systemic inflammatory response syndrome (SIRS), Huntington's disease, Alzheimer's disease, spinocerebral ataxia, Parkinson's disease , AIDS dementia complex, HIV infection, amyotrophic lateral sclerosis (ALS), depression, schizophrenia, sepsis, cardiogenic shock, severe trauma, acute lung injury, acute respiratory distress syndrome, acute cholecystitis, severe burns, pneumonia, major surgical interventions, ischemic bowel disease, severe acute liver disease, severe acute hepatic encephalopathy, or acute renal failure.

14 cl, 30 ex