METHOD FOR PRODUCING A BIODEGRADABLE COATING WITH HIGH HYDROPHILICITY BASED ON A BIOPOLYMER Russian patent published in 2021 - IPC A61L27/00 A61L27/28 A61L27/34 A61L27/58 C08J7/04 C08L101/16 

FIELD: medicine.

SUBSTANCE: invention relates to medicine, namely to a method for producing a coating with high hydrophilicity based on a biodegradable polymer. A method for producing a coating with high hydrophilicity based on a biodegradable polymer by applying a solution to the surface, including the surface of implants, followed by surface treatment in plasma is proposed. One of the following solvents with a boiling point of up to 110ºC or a mixture of them is used as the main solvent in the solution: tetrahydrofuran, dichloromethane, dioxane, ethyl acetate. For the preparation of the solution as a biodegradable polymer, a copolymer of lactide and caprolactone is used. In addition, substances that play the role of a modifying additive and represent at least one of the following substances are added to the solution from 0.5% to 20% by weight in relation to the main solvent: benzaldehyde, acetophenone. To remove the residual amount of the main solvent from the resulting coating, the coating is heat-treated at a temperature not exceeding the glass transition temperature of the biodegradable polymer. The subsequent treatment of the coating in plasma is carried out in a chamber with a low-temperature plasma formed by a high-frequency generator at a specific power of no more than 60 MW/cm² for no more than 100 s and an ion energy of less than 100 eV.

EFFECT: above method allows one to form coatings with a significant improvement in hydrophilicity – a decrease in the angle of wetting with water is about 5-10º, the method also allows achieving a significant increase in the retention time of the formed hydrophilicity of the surface.

3 cl, 2 ex