FIELD: biotechnology.
SUBSTANCE: invention relates to biotechnology. The present invention discloses nucleic acid molecules containing one or more nucleic acid sequences encoding a modified consensus mesothelin antigen. Described are vectors, compositions and vaccines containing one or more nucleic acid sequences encoding a modified consensus mesothelin antigen. Methods of treating a subject with a mesothelin-expressing tumor and methods of preventing a mesothelin-expressing tumor are disclosed. A modified consensus mesothelin antigen is disclosed.
EFFECT: invention makes it possible to obtain safe and effective vaccines in this field, which can be applied to mesothelin-expressing tumors, thus providing treatment and ensuring the survival of individuals affected by these types of cancer.
22 cl, 22 dwg, 17 tbl, 7 ex
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