MESOTHELINE-TARGETED CANCER VACCINES AND THEIR APPLICATION Russian patent published in 2021 - IPC C12N15/00 C12N15/86 C07K14/435 A61K48/00 

FIELD: biotechnology.

SUBSTANCE: invention relates to biotechnology. The present invention discloses nucleic acid molecules containing one or more nucleic acid sequences encoding a modified consensus mesothelin antigen. Described are vectors, compositions and vaccines containing one or more nucleic acid sequences encoding a modified consensus mesothelin antigen. Methods of treating a subject with a mesothelin-expressing tumor and methods of preventing a mesothelin-expressing tumor are disclosed. A modified consensus mesothelin antigen is disclosed.

EFFECT: invention makes it possible to obtain safe and effective vaccines in this field, which can be applied to mesothelin-expressing tumors, thus providing treatment and ensuring the survival of individuals affected by these types of cancer.

22 cl, 22 dwg, 17 tbl, 7 ex