FIELD: biotechnology.
SUBSTANCE: combinations for treating or preventing mesothelin-expressing cancer containing a nucleic acid molecule encoding a mesothelin antigen and an immune checkpoint inhibitor, and a vaccine for treating or preventing mesothelin-expressing cancer containing these combinations are provided. A method of treating a subject with a mesothelin-expressing tumor and a method of vaccinating a subject against a mesothelin-expressing cancer cell is also disclosed.
EFFECT: mesothelin-targeted cancer vaccines and their applications are proposed.
22 cl, 17 tbl, 12 dwg, 7 ex
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