FIELD: medicine; clinical laboratory diagnostics; nephrology.
SUBSTANCE: invention relates to medicine, namely to clinical laboratory diagnostics and nephrology, it can be used to diagnose hypoxia of the kidney parenchyma in experimental intraabdominal hypertension. The concentration of HIF-1a and VEGF-C biomarkers in the kidney tissue homogenate of rats with experimental intraabdominal hypertension is determined. If concentration of HIF-1a is above 13.6 ng/ml and concentration of VEGF-C is above 168.3 pg/ml, hypoxia of the kidney parenchyma is diagnosed.
EFFECT: method makes it possible to diagnose kidney hypoxia in experimental intraabdominal hypertension using a standardized method due to determining the concentration of HIF-1a and VEGF-C in the kidney homogenate of a laboratory animal using a solid-phase immunoassay analysis.
1 cl, 5 ex
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD OF DIAGNOSTICS OF KIDNEY DAMAGE IN CHILDREN WITH VESICOURETERAL REFLUX | 2023 |
|
RU2814399C1 |
| METHOD FOR DIAGNOSING ACUTE KIDNEY INJURY IN PREMATURE NEWBORNS BORN AT 32 WEEKS OF GESTATION AND LESS | 2023 |
|
RU2817171C1 |
| METHOD FOR FORECASTING SEVERITY OF EARLY PREECLAMPSY | 2021 |
|
RU2753463C1 |
| METHOD OF CREATING AN EXPERIMENTAL MODEL OF POSTOPERATIVE ISCHEMIA OF NEORECTUM | 2019 |
|
RU2719663C1 |
| METHOD OF CREATING AN EXPERIMENTAL MODEL OF POSTOPERATIVE ISCHEMIA NEORECTUM BY RECTAL TENSION | 2019 |
|
RU2719661C1 |
| METHOD FOR PREDICTION OF PESPONSE RATE TO IMMUNOSUPPRESSIVE THERAPY OF CHRONIC GLOMERULONEPHRITIS WITH NEPHROTIC SYNDROME | 2011 |
|
RU2453852C1 |
| METHOD FOR DIAGNOSING EARLY CHRONIC RENAL DISEASE IN CHILDREN | 2020 |
|
RU2753581C1 |
| METHOD FOR PREDICTING TUBULO-INTERSTITIAL KIDNEY DISEASE IN CHILDREN ASSOCIATED WITH HEMOLYTIC-UREMIC SYNDROME | 2021 |
|
RU2782125C1 |
| METHOD FOR THERAPEUTIC APPROACH SELECTION FOR PATIENTS WITH ACUTE DESCTRUCTIVE PANCREATITIS | 2016 |
|
RU2625742C1 |
| METHOD OF MEASURING INTRA-ABDOMINAL PRESSURE | 2012 |
|
RU2488346C1 |
