FIELD: medicine.
SUBSTANCE: group of inventions relates to medicine, namely to a method and device for continuous monitoring of glucose levels. When implementing the method, the device for continuous monitoring of glucose levels is calibrated taking into account the values of temperature and acidity of the biological fluid under study. Place it in contact with a biological fluid with the formation of a double layer on the electrodes. An electrical harmonic signal is applied to the electrodes at a frequency of 10-3-10 Hz. Direct electrochemical oxidation of glucose is performed on the Ag / AgCl reference electrode. The current in the circuit and the voltage between the electrodes are measured. The received data is processed using the Fourier transform. In the obtained spectrum, the second harmonic of the received signal is analyzed. Based on the level of this harmonic, a conclusion is made about the concentration of glucose in the biological fluid under study. The device contains a source of electrical harmonic oscillations, a sensor, a receiver of the analyzed signal. The vibration source is connected to the sensor. The sensor is connected to the receiver of the analyzed signal. The sensor contains a working electrode and a reference electrode, and is equipped with measuring the temperature and acidity of the biological fluid. The sensor elements are fixed on a biopassive dielectric substrate. The reference electrode is made of Ag / AgCl and allows direct electrochemical oxidation of glucose without the use of enzymes. The receiver of the analyzed signal includes an ADC with a bit width of at least 24. One of the ADC inputs is connected to a source of electrical harmonic oscillations to obtain a reference signal.
EFFECT: due to direct electrochemical oxidation of glucose without the use of enzymes and analysis of the second harmonic of the spectrum of the received signal, continuous measurement of glucose levels is ensured, and the measurement accuracy is increased.
3 cl, 4 dwg
