FIELD: medicine.
SUBSTANCE: invention relates to medicine, in particular to experimental pharmacology, and can be used to increase the survival rate of cell cultures. A method for increasing the survival of human endothelial cells is proposed, including modeling oxidative stress by adding a peptide with the amino acid sequence UEHLERALNSS or a peptide with the amino acid sequence UEQLERALNTS.
EFFECT: modeling oxidative stress in primary culture of human endothelial cells (HUVEC) by adding hydrogen peroxide H2O2 (200 mcM) led to significant cell death. Preliminary addition to the culture medium of a peptide with the amino acid sequence UEHLERALNSS (sample EP-11-1) or a peptide with the amino acid sequence UEQLERALNTS (sample EP-11-3) significantly increased the number of surviving cells under conditions of oxidative stress.
1 cl, 1 dwg, 1 tbl, 1 ex
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Authors
Dates
2021-07-13—Published
2021-02-18—Filed