METHOD FOR INCREASING THE SURVIVAL OF HUMAN ENDOTHELIAL CELLS Russian patent published in 2021 - IPC C07K7/06 A61K38/08 A61P9/00 

Abstract RU 2751332 C1

FIELD: medicine.

SUBSTANCE: invention relates to medicine, in particular to experimental pharmacology, and can be used to increase the survival rate of cell cultures. A method for increasing the survival of human endothelial cells is proposed, including modeling oxidative stress by adding a peptide with the amino acid sequence UEHLERALNSS or a peptide with the amino acid sequence UEQLERALNTS.

EFFECT: modeling oxidative stress in primary culture of human endothelial cells (HUVEC) by adding hydrogen peroxide H2O2 (200 mcM) led to significant cell death. Preliminary addition to the culture medium of a peptide with the amino acid sequence UEHLERALNSS (sample EP-11-1) or a peptide with the amino acid sequence UEQLERALNTS (sample EP-11-3) significantly increased the number of surviving cells under conditions of oxidative stress.

1 cl, 1 dwg, 1 tbl, 1 ex

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Authors

Antsiferov Oleg Vladimirovich

Korokin Mikhail Viktorovich

Gureev Vladimir Vladimirovich

Netrebenko Aleksandr Sergeevich

Soldatov Vladislav Olegovich

Pokrovskij Mikhail Vladimirovich

Pokrovskaya Tatyana Grigorevna

Peresypkina Anna Aleksandrovna

Gudyrev Oleg Sergeevich

Zatolokina Mariya Alekseevna

Pobeda Anna Sergeevna

Pokrovskij Vladimir Mikhajlovich

Yakushev Vladimir Ivanovich

Korokina Liliya Viktorovna

Gureeva Anastasiya Vladimirovna

Kochkarova Indira Sultanovna

Kolesnik Inga Mikhajlovna

Burda Yurij Evgenevich

Alekhin Sergej Aleksandrovich

Dates

2021-07-13Published

2021-02-18Filed