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2 731 919

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IPC

A61K38/08(2006-01-01)

A61K38/14(2006-01-01)

G09B23/28(2006-01-01)

A61P9/14(2006-01-01)

A61P15/00(2006-01-01)

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Application

2020112120, 2020-03-25

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Start date

2020-03-25

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Actual filing date

2020-03-25

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Published

2020-09-09

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Inventor

Gureev Vladimir VladimirovichGolubev Ivan VladimirovichSoldatov Vladislav OlegovichPokrovskij Mikhail VladimirovichPokrovskaya Tatyana GrigorevnaPeresypkina Anna AleksandrovnaKorokin Mikhail ViktorovichGdyrev Oleg SergeevichZatolokina Mariya AlekseevnaPobeda Anna SergeevnaYakushev Vladimir IvanovichKorokina Liliya ViktorovnaLazareva Galina AnatolevnaGureeva Elena Gennadievna

(73)

Holder

Federalnoe Gosudarstvennoe Avtonomnoe Obrazovatelnoe Uchrezhdenie Vysshego Obrazovaniya Gosudarstvennyj Natsionalnyj Issledovatelskij Universitet"

METHOD OF PLACENTAL MICROCIRCULATION CORRECTION BY PEPTIDE IMITATING B ERYTHROPOIETIN ALPHA-SPIRAL WITH ADMA-LIKE PRE-ECLAMPSIA MODEL Russian patent published in 2020 - IPC A61K38/08 A61K38/14 G09B23/28 A61P9/14 A61P15/00

Abstract RU 2731919 C1

FIELD: medicine.

SUBSTANCE: invention refers to medicine, particularly to experimental pharmacology, and can be used for correction of placental microcirculation disorders. That is ensured by reproducing the pre-eclampsia model in the Wistar rats by intraperitoneal introduction of L-nitro-arginine-methyl ester 25 mg/kg daily from 14th to 20th day of pregnancy. Correction of simulated pathology is performed by intraperitoneal introduction of peptide imitating α-helix of B erythropoietin (P-αB) in dose 50 mcg/kg/day from 10th to 20th day of pregnancy.

EFFECT: method results in pronounced correction of endothelial dysfunction under conditions of reproduced ADMA-like model of preeclampsia in pregnant rats.

1 cl, 1 tbl, 1 ex

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RU 2 731 919 C1

Authors

Gureev Vladimir Vladimirovich

Golubev Ivan Vladimirovich

Soldatov Vladislav Olegovich

Pokrovskij Mikhail Vladimirovich

Pokrovskaya Tatyana Grigorevna

Peresypkina Anna Aleksandrovna

Korokin Mikhail Viktorovich

Gdyrev Oleg Sergeevich

Zatolokina Mariya Alekseevna

Pobeda Anna Sergeevna

Yakushev Vladimir Ivanovich

Korokina Liliya Viktorovna

Lazareva Galina Anatolevna

Gureeva Elena Gennadievna

Dates

2020-09-09—Published

2020-03-25—Filed