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2 724 402

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IPC

G09B23/28(2006-01-01)

A61K38/14(2006-01-01)

A61P15/00(2006-01-01)

(21) (22)

Application

2020112218, 2020-03-25

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Start date

2020-03-25

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Actual filing date

2020-03-25

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Published

2020-06-23

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Inventor

Gureev Vladimir VladimirovichGolubev Ivan VladimirovichSoldatov Vladislav OlegovichPokrovskij Mikhail VladimirovichPokrovskaya Tatyana GrigorevnaPeresypkina Anna AleksandrovnaKorokin Mikhail ViktorovichGudyrev Oleg SergeevichZatolokina Mariya AlekseevnaPobeda Anna SergeevnaYakushev Vladimir IvanovichKorokina Liliya ViktorovnaLazareva Galina AnatolevnaGureeva Elena Gennadievna

(73)

Holder

Federalnoe Gosudarstvennoe Avtonomnoe Obrazovatelnoe Uchrezhdenie Vysshego Obrazovaniya Gosudarstvennyj Natsionalnyj Issledovatelskij Universitet"

METHOD OF CORRECTION OF STRUCTURAL DAMAGES IN PLACENTA WITH PEPTIDE IMITATING ALPHA-HELIX B ERYTHROPOIETIN IN ADMA-LIKE MODEL OF PREECLAMPSIA Russian patent published in 2020 - IPC G09B23/28 A61K38/14 A61P15/00

Abstract RU 2724402 C1

FIELD: medicine.

SUBSTANCE: invention refers to medicine, particularly to experimental pharmacology, and can be used for correction of structural damages of placental tissues. That is ensured by intraperitoneal introduction of L-nitro-arginine-methyl ester 25 mg/kg daily in the Wistar rats from 14th to 20th day of pregnancy reproducing the pre-eclampsia model. Correction of structural damages of placental tissues is carried out by introducing a peptide imitating α-helix of B erythropoietin P-αB intraperitoneal administration in dose of 50 mcg/kg/day from 10 to 20 days of pregnancy.

EFFECT: method enables correcting structural damages of placental tissues in conditions of reproducible ADMA similar model of preeclampsia in pregnant rats.

1 cl, 1 tbl, 1 ex

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RU 2 724 402 C1

Authors

Gureev Vladimir Vladimirovich

Golubev Ivan Vladimirovich

Soldatov Vladislav Olegovich

Pokrovskij Mikhail Vladimirovich

Pokrovskaya Tatyana Grigorevna

Peresypkina Anna Aleksandrovna

Korokin Mikhail Viktorovich

Gudyrev Oleg Sergeevich

Zatolokina Mariya Alekseevna

Pobeda Anna Sergeevna

Yakushev Vladimir Ivanovich

Korokina Liliya Viktorovna

Lazareva Galina Anatolevna

Gureeva Elena Gennadievna

Dates

2020-06-23—Published

2020-03-25—Filed