SARS-CoV-2 CORONAVIRUS REPLICATION INHIBITOR BASED ON HUMIC SUBSTANCES Russian patent published in 2021 - IPC A61K36/06 A61K35/10 B01D11/02 A61P31/14 

FIELD: pharmaceutical industry.

SUBSTANCE: group of inventions relates to the pharmaceutical industry, namely to the use of water-soluble humic substances from brown coal or from chaga to inhibit the replication of the SARS-CoV-2 coronavirus. The use of water-soluble humic substances from brown coal obtained as a result of the exothermic reaction of crushed brown coal in a mixture of 2% ammonia and hydrogen peroxide, followed by precipitation and re-precipitation of humic substances with hydrochloric acid, dilution in water at pH 7.0-8.0, drying, with or without trypsin treatment, to inhibit the replication of the SARS-CoV-2 coronavirus, which, at concentrations in the range of 14.34-23.1 mcg/ml, exhibit a 50% antiviral dose-dependent activity against SARS-CoV-2 in tests on Vero cell cultures. The use of water-soluble humic substances from the chaga, basid fungus Inonotus obliquus, obtained as a result of the exothermic reaction of crushed chaga in a mixture of 2% ammonia and hydrogen peroxide, followed by precipitation and re-precipitation of humic substances with hydrochloric acid, dilution in water at pH 7.0-8.0, drying, treatment with trypsin, to inhibit the replication of the SARS-CoV-2 coronavirus, which at a concentration of 23.447 mcg/ml exhibit 50% antiviral dose-dependent inhibitory activity against SARS-CoV-2 in Vero cell culture tests.

EFFECT: above-described use of humic substances is effective for inhibiting the replication of the SARS-CoV-2 coronavirus.

2 cl, 1 dwg, 1 tbl, 8 ex