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RU

(11)

2 747 018

(13)

C1

(51)

IPC

A61K36/06(2006-01-01)

B01D11/02(2006-01-01)

A61P31/14(2006-01-01)

(21) (22)

Application

2020133916, 2020-10-14

(24)

Start date

2020-10-14

(22)

Actual filing date

2020-10-14

(45)

Published

2021-04-23

(72)

Inventor

Teplyakova Tamara VladimirovnaPyankov Oleg ViktorovichSkarnovich Maksim OlegovichBormotov Nikolaj IvanovichPoteshkina Alevtina LeonidovnaOvchinnikova Alena SergeevnaKosogova Tatyana AlekseevnaMagerramova Anastasiya ViktorovnaMarkovich Nataliya AlekseevnaFilippova Ekaterina Igorevna

(73)

Holder

Federalnoe Byudzhetnoe Uchrezhdenie Nauki Nauchnyj Tsentr Virusologii I Biotekhnologii Federalnoj Sluzhby Po Nadzoru V Sfere Zashity Prav Potrebitelej I Blagopoluchiya Cheloveka Gnts Vb Rospotrebnadzora)

SARS-COV-2 CORONAVIRUS REPLICATION INHIBITOR BASED ON MELANIN FROM INONOTUS OBLIQUUS FUNGUS Russian patent published in 2021 - IPC A61K36/06 B01D11/02 A61P31/14 

Abstract RU 2747018 C1

FIELD: pharmaceuticals.

SUBSTANCE: present invention relates to the pharmaceutical industry, namely, to a replication inhibitor of the SARS-CoV-2 coronavirus that causes severe acute respiratory syndrome COVID-19. The natural melanin from the basidiomycetes Inonotus obliquus is used, obtained by alkaline hydrolysis of Inonotus obliquus, acid precipitation, dissolution of the precipitate in ammonia water and drying of the final product at a temperature not exceeding 30-40ºC, as a replication inhibitor of SARS coronavirus. An aqueous solution of this inhibitor in the range of 6,218-8,488 mcg/ml exhibits 50% antiviral dose-dependent activity against SARS-CoV-2 in tests on Vero cell culture.

EFFECT: above-described natural melanin exhibits 50% antiviral dose-dependent activity against SARS-CoV-2 in Vero cell culture tests.

1 cl, 1 dwg, 1 tbl, 5 ex

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RU 2 747 018 C1

Authors

Teplyakova Tamara Vladimirovna

Pyankov Oleg Viktorovich

Skarnovich Maksim Olegovich

Bormotov Nikolaj Ivanovich

Poteshkina Alevtina Leonidovna

Ovchinnikova Alena Sergeevna

Kosogova Tatyana Alekseevna

Magerramova Anastasiya Viktorovna

Markovich Nataliya Alekseevna

Filippova Ekaterina Igorevna

Dates

2021-04-23—Published

2020-10-14—Filed

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