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2 758 383

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IPC

C07D498/14(2006-01-01)

C07D513/14(2006-01-01)

A61K31/5365(2006-01-01)

A61K31/542(2006-01-01)

A61P31/04(2006-01-01)

A61P31/10(2006-01-01)

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Application

2021110962, 2021-04-16

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Start date

2021-04-16

(22)

Actual filing date

2021-04-16

(45)

Published

2021-10-28

(72)

Inventor

Maslivets Andrej NikolaevichBalandina Svetlana YurevnaKhramtsova Ekaterina EvgenevnaKrajnov Aleksandr Denisovich

(73)

Holder

Federalnoe Gosudarstvennoe Avtonomnoe Obrazovatelnoe Uchrezhdenie Vysshego Obrazovaniya Gosudarstvennyj Natsionalnyj Issledovatelskij Universitet"

METHOD FOR PRODUCING 2-(DIALKYLAMINO)-4-ARYL-7,7A-DIHYDROPYRROLO[2,3-D][1,3]OXAZINE-5,6-DIONES ANNELATED ON THE SIDE OF [1,2] GETAREN FRAGMENT Russian patent published in 2021 - IPC C07D498/14 C07D513/14 A61K31/5365 A61K31/542 A61P31/04 A61P31/10

Abstract RU 2758383 C1

FIELD: organic chemistry.

SUBSTANCE: invention relates to organic chemistry field, specifically to a method for producing 2-(dialkylamino)-4-aryl-7,7a-dihydropyrrolo[2,3-d][1,3]oxazine-5,6-diones annelated on the side of [1,2] by a getarene fragment (IIIa-в, where X = NPh, R = Ph, Y = CH₃ (a); X = NPh, R = Ph, Y+Y = -(CH₂)₅- (б); X = S, R = Ph, Y+Y = -CH₂CH₂OCH₂CH₂- (в)). Method is carried out by interaction of getareno[e]pyrrole-2,3-diones (Ia, б, where X = NPh, R = Ph (a); X = S, R = Ph (б).) with substituted cyanamides (IIa-в, where Y = CH₃ (a); Y +Y = -(CH₂)₅- (б); Y+Y = - CH₂CH₂OCH₂CH₂- (в)) in inert ambient aprotic solvents with subsequent formation of desired products.

EFFECT: method for synthesis of 2-(dialkylamino)-4-aryl-7,7a-dihydropyrrolo[2,3-d][1,3]oxazine-5,6-diones annelated on the side of [1,2] by a hetaren fragment (IIIa-в) has been developed, which can be used as primary products for synthesis of new heterocyclic systems and in pharmacology.

1 cl, 1 tbl, 4 ex

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RU 2 758 383 C1

Authors

Maslivets Andrej Nikolaevich

Balandina Svetlana Yurevna

Khramtsova Ekaterina Evgenevna

Krajnov Aleksandr Denisovich

Dates

2021-10-28—Published

2021-04-16—Filed