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2 758 545

(13)

C1

(51)

IPC

G09B23/28(2006-01-01)

A61K31/495(2006-01-01)

A61P25/00(2006-01-01)

(21) (22)

Application

2021108391, 2021-03-29

(24)

Start date

2021-03-29

(22)

Actual filing date

2021-03-29

(45)

Published

2021-10-29

(72)

Inventor

Antsiferov Oleg ViktorovichKorokin Mikhail ViktorovichGureev Vladimir VladimirovichCherevatenko Roman FedorovichNetrebenko Aleksandr SergeevichPokrovskij Mikhail VladimirovichPokrovskaya Tatyana GrigorevnaBelyaeva Veronika SergeevnaGudyrev Oleg SergeevichZatolokina Mariya AlekseevnaPokrovskij Vladimir MikhajlovichGureeva Anastasiya VladimirovnaPatrakhanov Evgenij AleksandrovichNesterov Arkadij VitalevichNesterova Natalya IgorevnaMartynova Olga ViktorovnaDanilenko Lyudmila MikhajlovnaTrunov Konstantin SergeevichStepenko Yuliya VladimirovnaTsuverkalova Yuliya Mikhajlovna

(73)

Holder

Federalnoe Gosudarstvennoe Avtonomnoe Obrazovatelnoe Uchrezhdenie Vysshego Obrazovaniya Gosudarstvennyj Natsionalnyj Issledovatelskij Universitet"

METHOD FOR CORRECTING MORPHOLOGICAL CHANGES IN TRAUMATIC BRAIN INJURY Russian patent published in 2021 - IPC G09B23/28 A61K31/495 A61P25/00 

Abstract RU 2758545 C1

FIELD: medicine.

SUBSTANCE: invention relates to medicine, in particular to experimental pharmacology, and can be used to correct structural damage to the brain in traumatic brain injury. A method for correcting morphological changes in the brain in traumatic brain injury involves reproducing traumatic brain injury in male rats weighing 270±20 g. To correct morphological changes, trimetazidine is administered intragastrically at a dose of 6.6 mg/kg per day, divided by 2 reception with an interval of 12 hours from 1 to 7 days of the experiment, inclusive. Wherein trimetazidine begins to be administered 2 hours before the simulation of the experimental traumatic brain injury.

EFFECT: invention provides an effective method for correcting morphological changes in the brain in an experimental model of traumatic brain injury.

1 cl, 13 dwg, 1 ex

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RU 2 758 545 C1

Authors

Antsiferov Oleg Viktorovich

Korokin Mikhail Viktorovich

Gureev Vladimir Vladimirovich

Cherevatenko Roman Fedorovich

Netrebenko Aleksandr Sergeevich

Pokrovskij Mikhail Vladimirovich

Pokrovskaya Tatyana Grigorevna

Belyaeva Veronika Sergeevna

Gudyrev Oleg Sergeevich

Zatolokina Mariya Alekseevna

Pokrovskij Vladimir Mikhajlovich

Gureeva Anastasiya Vladimirovna

Patrakhanov Evgenij Aleksandrovich

Nesterov Arkadij Vitalevich

Nesterova Natalya Igorevna

Martynova Olga Viktorovna

Danilenko Lyudmila Mikhajlovna

Trunov Konstantin Sergeevich

Stepenko Yuliya Vladimirovna

Tsuverkalova Yuliya Mikhajlovna

Dates

2021-10-29—Published

2021-03-29—Filed

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