METHOD FOR DIAGNOSING ACUTE REJECTION OF TRANSPLANT IN TRANSPLANTED HEART RECIPIENT Russian patent published in 2021 - IPC G01N33/48 

Abstract RU 2758973 C1

FIELD: medicine.

SUBSTANCE: invention relates to medicine, namely organ transplantation and clinical laboratory diagnostics; it can be used in the management of patients after transplantation to diagnose acute rejection of the transplanted heart. To diagnose acute transplant rejection in heart recipients, the expression level of microRNA-27 is determined in venous blood plasma and, at a level below -5.07 relative units, the presence of acute transplant rejection is diagnosed.

EFFECT: ensuring the availability and non-invasiveness of diagnostics, reducing the time of its implementation, while achieving reliable diagnostics of acute transplant rejection, as well as increasing the survival rate of recipients and improving the results of heart transplantation due to timely determining indications for unscheduled endomyocardial biopsy by determining the expression level of microRNA-27 in venous blood plasma.

1 cl, 3 ex

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RU 2 758 973 C1

Authors

Velikij Dmitrij Alekseevich

Gichkun Olga Evgenevna

Mozhejko Natalya Pavlovna

Stakhanova Ekaterina Anatolevna

Ulybysheva Adelya Anverovna

Shevchenko Olga Pavlovna

Shevchenko Aleksej Olegovich

Dates

2021-11-03Published

2020-12-23Filed