METHOD FOR ADJUVANT ADAPTIVE STEREOTACTIC RADIATION THERAPY IN THE TREATMENT OF PRIMARY MALIGNANT GLIAL BRAIN TUMORS Russian patent published in 2021 - IPC A61N5/01 

FIELD: medicine.

SUBSTANCE: invention relates to medicine, namely to oncology and radiotherapy, and can be used for adjuvant, adaptive stereotactic radiation therapy in the treatment of primary malignant glial brain tumors. A postoperative patient with a verified diagnosis, no later than one month after the operation, undergoes magnetic resonance imaging (MRI) of the brain with intravenous contrast enhancement in 3-D Bravo mode. A three-layer stereotaxic mask is prepared for the patient. Topometric spiral X-ray computed tomography of the brain is performed. Next, multimodal images are combined in specialized software, the boundaries of the irradiation target are determined. Next, radiation therapy of the target area is carried out up to total boost dose 60 Gy with single boost dose 2 Gy, the offset for the clinical target volume is 20 mm with volume correction according to T2 Flair, the offset for the planned target volume is 1 mm from the macroscopic tumor volume. Radiation therapy is carried out along with dexamethasone 4.0 mg/ml twice a day, intramuscularly. Before the start of treatment, on the 10th, 20th and 30th fractions of treatment, MRI of the brain is performed with the obligatory inclusion of the T2 FLAIR mode, followed by the determination of the volume of the irradiated tissue and the development of a new radiation therapy plan.

EFFECT: method provides reduction of radiation load on critical structures and healthy brain tissues due to super-high degree of patient fixation with three-layer stereotaxic mask, correction of radiation therapy plan in dynamics by performing MRI of the brain.

1 cl, 1 ex