APPLICATION OF Fe-Fe O NANOPARTICLES WITH A CORE-SHELL STRUCTURE TO INCREASE THE SENSITIVITY OF BACTERIA TO ANTIBIOTICS Russian patent published in 2021 - IPC A61K31/43 A61K31/7036 A61K33/26 A61P17/02 A61P31/04 

FIELD: medicine.

SUBSTANCE: invention relates to the field of medicine and pharmaceuticals, namely, to an application of Fe-Fe₃O₄ (iron-iron oxide) nanoparticles with a core-shell structure, wherein the core is Fe and the shell is Fe₃O₄, as a means of increasing the sensitivity of bacteria of resistant strains such as Pseudomonas aeruginosa and Staphylococcus aureusto antibiotics such as ampicillin and amikacin, in treatment of wounds, wherein the nanoparticles are selected from 1) those with a positive zeta potential in deionised water at a pH of 7.4 and a temperature of 37°C of 9.6±1.8 mV, the value of the specific surface area of 6.7±0.9 m²/g, the content of iron oxide (Fe₃O₄) of 39 wt.%, and the average particle size of 81±5 nm or 2) those with a positive zeta potential in deionised water at a pH of 7.4 and a temperature of 37°C of 10.4±2.3 mV, the value of the specific surface area of 7.3±0.8 m²/g, the content of iron oxide (Fe₃O₄) of 92 wt.%, and the average particle size of 78±3 nm.

EFFECT: reduced dosage of the antibiotic, possibility of applying low-toxic antibiotics, increased effectiveness of treatment.

7 cl, 5 tbl, 2 ex