METHOD FOR FORMING PHENOTYPES OF THE RISK OF DEVELOPING CHRONIC OBSTRUCTIVE PULMONARY DISEASE IN YOUNG PEOPLE AGED 11 TO 23 YEARS Russian patent published in 2021 - IPC A61B5/08 

FIELD: medicine.

SUBSTANCE: invention relates to medicine, namely to pulmonology, and can be used in the formation of risk phenotypes for the development of chronic obstructive pulmonary disease (COPD) in persons from 11 to 23 years old. To do this, the patient is given a comprehensive analysis of clinical, laboratory and instrumental indicators, including the main indicators of spirometry: the volume of forced exhalation in the first second (FEV1), the forced vital capacity of the lungs (FVC), the Tiffeneau index, expressed as the ratio of FEV1 to FVC. Based on the questionnaire, such differential indicators as the frequency of acute respiratory infections (ARI) per year and the smoking index are evaluated. Based on the CAT test (COPD Assessment test), the presence/absence of cough and its severity, as well as the presence/absence of sputum discharge, are evaluated. The severity of respiratory noises during electronic auscultation, an assessment of the concentration of oxygen O₂, an assessment of the concentration of carbon monoxide in the blood expressed in permille, an assessment of the concentration of alpha-1-antitrypsin (AAT) in the blood and an assessment of polymorphism for the specific SERPINA-1 gene are also carried out. After that, the phenotype of the risk of developing chronic obstructive pulmonary disease is determined according to the original mathematical formula with the assignment of points. With a total score of 0-10, phenotype 1 is determined to be low risk, 11-23 points, phenotype 2, moderate risk, 24-30 points, phenotype 3, high risk, more than 30, phenotype 4, extremely high risk of COPD.

EFFECT: method provides identification of patients with certain risk phenotypes, simplification of diagnosis, improvement of primary, secondary and tertiary prevention measures and, as a result, increased effectiveness of COPD prevention and improvement of patients’ quality of life.

1 cl, 1 tbl, 1 dwg, 4 ex