METHOD FOR DIAGNOSING THE STAGE OF LIVER FIBROSIS IN CHRONIC LIVER DISEASES IN CHILDREN Russian patent published in 2021 - IPC G01N33/483 G01N33/50 

FIELD: medicine.

SUBSTANCE: invention relates to medicine, namely to infectious diseases. The following laboratory parameters are determined: international normalized ratio, the concentration of albumin, highly sensitive C-reactive protein. The obtained values ​​are entered into the formula for calculating linear discriminant functions LDF1=-102.2+40.7X1+3.9X2-0.9X3, LDF2=-96.9+50.3X1+3.5X2-0.26X3, where X1 - international normalized ratio, X2 - concentration of albumin in g/l, X3 - concentration of highly sensitive C-reactive protein in mg/l. Then the values ​​of the indicators are compared and with LDF1>LDF2 - minimal liver fibrosis is diagnosed, with LDF2>LDF1 - high-grade liver fibrosis.

EFFECT: method allows early diagnosis of the stage of fibrosis, promotes the appointment of timely therapy aimed at reducing the rate of progression of fibrosis, improving the quality of life of the child and preventing the development of cirrhosis and hepatocellular carcinoma of the liver.

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