AFFINE MOLECULE-OLIGONUCLEOTIDE CONJUGATES AND THEIR APPLICATIONS Russian patent published in 2021 - IPC C12Q1/68 C12N15/10 C40B30/04 C12N5/783 

Abstract RU 2763554 C2

FIELD: biotechnology.

SUBSTANCE: invention relates to the field of biotechnology, specifically to a method for selecting T-cell receptor (hereinafter – TCR). The proposed method includes the attachment of a drop barcode-labeled polynucleotide to an oligonucleotide part of a molecule of pMHC-oligonucleotide conjugate in a drop and TCR polynucleotide of an isolated T-cell of a set of T-cells.

EFFECT: proposed method allows for the identification of isolated T-cells for their subsequent sequencing.

93 cl, 21 dwg, 1 tbl, 22 ex

Similar patents RU2763554C2

Title Year Author Number
AFFINITY CONJUGATES - OLIGONUCLEOTIDE AND THEIR APPLICATIONS 2016
  • Vino, Fransua
  • Briggs, Adrian Rengem
  • Goldfless, Stiven Dzh.
  • Belmont, Brajan Dzh.
RU2778754C2
HIGH THROUGHPUT SEQUENCING OF POLYNUCLEOTIDE LIBRARIES AND TRANSCRIPTOME ANALYSIS 2018
  • Goldfless, Stephen Jacob
  • Briggs, Adrian Wrangham
  • Chari, Rajagopal
  • Jiang, Yue
  • Hause, Ronald
  • Vigneault, Francois
RU2790291C2
COMPOSITIONS AND METHODS OF MEASUREMENT AND CALIBRATION OF SYSTEMATIC MISTAKE OF AMPLIFICATION IN MULTIPLEX PCR-REACTIONS 2013
  • Robins Kharlan S.
  • Karlson Kristofer S.
  • Livingston Robert Dzh.
  • Emerson Rajan O.
  • Shervud Anna
RU2631797C2
METHOD AND COMPOSITION FOR ANALYZING CELLULAR COMPONENTS 2016
  • Gunderson Kevin L.
  • Stimers Frenk Dzh.
  • Fisher Dzheffri S.
  • Rigatti Roberto
RU2717491C2
IDENTIFICATION OF POLYNUCLEOTIDES ASSOCIATED WITH SAMPLE 2012
  • Robinson William H.
  • Tan Yann Chong
  • Sokolove Jeremy
RU2644681C2
METHODS AND MEANS OF PRODUCING SEQUENCING LIBRARY 2019
  • Stimers, Frenk Dzh.
  • Pokholok, Dmitrij K.
  • Kristiansen, Lena
RU2815513C2
COMPOSITIONS FOR T-CELL THERAPY WITH CHIMERIC ANTIGEN RECEPTOR AND USE THEREOF 2018
  • Irvine, Darrell, J.
  • Ma, Leyuan
RU2819805C2
CONSTRUCTED HIGH-AFFINITY HUMAN T-CELL RECEPTORS 2014
  • Smith, Sheena N.
  • Harris, Daniel T.
  • Kranz, David M.
RU2729383C2
CONSTRUCTED HIGH-AFFINITY HUMAN T-CELL RECEPTORS 2014
  • Smith, Sheena N.
  • Harris, Daniel T.
  • Kranz, David M.
  • Schmitt, Thomas M.
  • Greenberg, Philip D.
RU2740648C2
MPHOSPH1 PEPTIDES AND VACCINES CONTAINING THEM 2012
RU2612905C2

RU 2 763 554 C2

Authors

Vigneault, Francois

Briggs, Wrangham, Adrian

Goldfless, Stephen J.

Belmont, Brian J.

Dates

2021-12-30Published

2017-01-12Filed