Show metadata Hide metadata

(19)

(11)

2 763 735

(13)

(51)

IPC

A61K31/381(2006-01-01)

A61P31/00(2006-01-01)

(21) (22)

Application

2021119245, 2021-06-29

(24)

Start date

2021-06-29

(22)

Actual filing date

2021-06-29

(45)

Published

2021-12-30

(72)

Inventor

Shipilovskikh Sergej AleksandrovichRubtsov Aleksandr EvgenevichMakhmudov Ramiz RagibovichShipilovskikh Darya AleksandrovnaTkachenko Aleksandr GeorgievichNesterova Larisa Yurevna

(73)

Holder

Federalnoe Gosudarstvennoe Avtonomnoe Obrazovatelnoe Uchrezhdenie Vysshego Obrazovaniya Gosudarstvennyj Natsionalnyj Issledovatelskij Universitet"

APPLICATION OF ANTIMICROBIAL AGENT FOR GOLDEN STAPHYLOCOCCUS WITH MULTIPLE DRUG RESISTANCE BASED ON 2-((4-R1-5-R2-3-(ETHOXICARBONYL)THIOPHENE-2-YL)AMINO-4-R3-OXO-ENOIC ACIDS Russian patent published in 2021 - IPC A61K31/381 A61P31/00

Abstract RU 2763735 C1

FIELD: chemistry.

SUBSTANCE: invention relates to the use of 2-((4-R1-5-R2-3-(ethoxycarbonyl)thiophen-2-yl)amino)-4-oxo-4-R3-but-2-enoic acids of general formula 1а, б as an antimicrobial agent.

EFFECT: compounds have been obtained in high yields with pronounced antimicrobial activity against Staphylococcus aureus with multidrug resistance, as well as low toxicity.

1 cl, 4 ex

Similar patents RU2763735C1

Title	Year	Author	Number
APPLICATION OF ANTIFUNGAL AGENT BASED ON 2-((4-R1-5-R2-3-(ETHOXYCARBONYL)THIOPHENE-2-IL)AMINO)-4-OXO-4-R3-BUT-2-ENO ACIDS IN RELATION TO CANDIDA ALDICANS	2021	Shipilovskikh Sergej Aleksandrovich Rubtsov Aleksandr Evgenevich Makhmudov Ramiz Ragibovich Shipilovskikh Darya Aleksandrovna Tkachenko Aleksandr Georgievich Nesterova Larisa Yurevna	RU2770598C1
(Z)-2-((4-R-5-R-3-(ETHOXYCARBONYL)THIOPHEN-2-YL)AMINO)-4-OXO-4-R-BUT-2-ENE ACIDS, HAVING ANTIMICROBIAL ACTIVITY	2019	Shipilovskikh Sergej Aleksandrovich Rubtsov Aleksandr Evgenevich Makhmudov Ramiz Ragibovich	RU2722176C1
USE OF AN ANTIFUNGAL AGENT BASED ON ETHYL ESTER OF 2-[(5-(4-METHOXYPHENYL)-2-OXOFURAN-3(2H)-YLIDENE)AMINO]-4,5,6,7-TETRAHYDROBENZO[b]THIOPHENE-3-CARBOXYLIC ACID	2021	Shipilovskikh Sergej Aleksandrovich Rubtsov Aleksandr Evgenevich Makhmudov Ramiz Ragibovich Shipilovskikh Darya Aleksandrovna Tkachenko Aleksandr Georgievich Nesterova Larisa Yurevna	RU2766564C1
4-(4-METHYLPHENYL)-4-OXO-2-[3-(ETHOXYCARBONYL-4,5-R,R-THIOPHEN-2-YLAMINO]BUT-2-ENOIC ACID, HAVING ANTI-INFLAMMATORY AND ANALGESIC ACTIVITY	2008	Shipilovskikh Sergej Aleksandrovich Rubtsov Aleksandr Evgen'Evich Makhmudov Ramiz Ragipovich Zalesov Vladimir Vasil'Evich	RU2389724C1
4-(4-BROMOPHENYL)-4-OXO-2-{[3-ETHOXYCARBONYL)-4,5-DIMETHYLTHIEN-2-YL]AMINO}-2-BUTENOIC ACID, HAVING ANTI-INFLAMMATORY AND ANALGESIC ACTIVITY	2012	Makhmudov Ramiz Ragibovich Rubtsov Aleksandr Evgen'Evich Shipilovskikh Sergej Aleksandrovich	RU2485112C1
APPLICATION OF 2-[(3-(AMINOCARBONIL)-4,5,6,7-TETRAHYDROBENZO[b]THIOPHEN-2-yl)AMINO]-4-OXO-4-(4-CHLOROPHENYL)BUT-2-ENOIC ACID IN AS AN ANTI-INFLAMMATORY DRUG	2022	Shipilovskikh Sergei Aleksandrovich Makhmudov Ramiz Ragibovich Rubtsov Aleksandr Evgenevich	RU2785780C1
AMIDE (E)-2-AMINO-4-OXO-5-(2-OXO-2-PHENYLETHYLIDENE)-1-(3-ETHOXYCARBONYL)-4,5,6-7-TETRAHYDROBENZO[B]THIOPHEN-2-YL)4,5-DIHYDRO-1H-PYRROLE-3-CARBOXYLIC ACID, HAVING ANTIMICROBIAL ACTIVITY	2020	Shipilovskikh Sergej Aleksandrovich Rubtsov Aleksandr Evgenevich Makhmudov Ramiz Ragibovich Tkachenko Aleksandr Georgievich Nesterova Larisa Yurevna	RU2738405C1
USE OF ETHYL-4-(4-HYDROXY-2-OXO-4-(THIOPHENE-2-YL)BUT-3-ENTHIOAMIDO)BENZOATE FOR TREATMENT OF DISEASES CAUSED BY GOLDEN STAPHYLOCOCCUS	2022	Rubtsov Aleksandr Evgenevich Nasibullina Ekaterina Ramilevna Makhmudov Ramiz Ragibovich Balandina Svetlana Iurevna	RU2785779C1
4-OXO-4-(THIOPHEN-2-YL)-2-{[4-(4-CHLOROPHENYL)-3-(ETHOXYCARBONYL)THIOPHEN-2-YL]AMINO} BUT-2-ENOIC ACID WITH ANALGESIC ACTIVITY	2023	Shipilovskikh Sergei Aleksandrovich Makhmudov Ramiz Ragibovich Gorbunova Irina Aleksandrovna Nikonov Ivan Pavlovich	RU2810071C1
APPLICATION OF 4-(4-METHOXYPHENYL)-4-OXO-2-[(3-(CYANO)-4,5,6,7-TETRAHYDROBENZO[b]THIOPHEN-2-yl)AMINO]BUT-2-ENOIC ACID AS AN ANALGESIC DRUG	2022	Shipilovskikh Sergei Aleksandrovich Makhmudov Ramiz Ragibovich Rubtsov Aleksandr Evgenevich	RU2785784C1

RU 2 763 735 C1

Authors

Shipilovskikh Sergej Aleksandrovich

Rubtsov Aleksandr Evgenevich

Makhmudov Ramiz Ragibovich

Shipilovskikh Darya Aleksandrovna

Tkachenko Aleksandr Georgievich

Nesterova Larisa Yurevna

Dates

2021-12-30—Published

2021-06-29—Filed