NEW METHODS FOR TREATING MULTIPLE SCLEROSIS Russian patent published in 2022 - IPC A61K31/4439 A61P25/28 

FIELD: medicine.

SUBSTANCE: group of inventions relates to the field of medicine, namely, to neurology, and is intended for treating such demyelinating diseases as multiple sclerosis, amyotrophic lateral sclerosis, and Alzheimer's disease. In order to treat the above demyelinating diseases, an effective amount of 4–(2–((1R,2R)–2–hydroxycyclohexylamino)benzothiazole–6–iloxy)–N–methylpicolinamide or a pharmacologically acceptable salt thereof is administered to the subject in need of such treatment. In one embodiment, the effective amount of 4–(2–((1R,2R)-2-hydroxycyclohexylamino)benzothiazole–6–iloxy)–N–methylpicolinamide or a pharmacologically acceptable salt thereof ranges from 250 mg to 350 mg per day. In another embodiment, the effective amount of 4–(2–((1R,2R)-2-hydroxycyclohexylamino)benzothiazole–6–iloxy)–N–methylpicolinamide or a pharmacologically acceptable salt thereof is administered in combination with another therapeutic agent.

EFFECT: use of the group of inventions provides a possibility of enhancing the central restorative remyelination mechanisms by modulating neuroinflammation, thereby providing effective treatment of such demyelinating diseases as multiple sclerosis, amyotrophic lateral sclerosis, and Alzheimer's disease.

18 cl, 11 dwg, 3 ex