Show metadata Hide metadata

(19)

(11)

2 766 608

(13)

(51)

IPC

C07K16/18(2006-01-01)

C07K16/28(2006-01-01)

C07K14/705(2006-01-01)

A61K39/395(2006-01-01)

A61P35/00(2006-01-01)

A61P35/02(2006-01-01)

(21) (22)

Application

2018111462, 2013-03-15

(24)

Start date

2013-03-15

(22)

Actual filing date

2013-03-15

(45)

Published

2022-03-15

(72)

Inventor

Kokhenderfer Dzhejms Nobl

(73)

Holder

The United States Of America, As Represented By The Secretary, Department Of Health And Human Services

CHIMERIC ANTIGEN RECEPTORS TARGETED B-CELL MATURATION ANTIGEN Russian patent published in 2022 - IPC C07K16/18 C07K16/28 C07K14/705 A61K39/395 A61P35/00 A61P35/02

Abstract RU 2766608 C2

FIELD: biotechnology.

SUBSTANCE: invention relates to the field of biotechnology, in particular to a chimeric antigen receptor (hereinafter – CAR) targeted against B-cell maturation antigen (hereinafter – BCMA), as well as to a composition containing it. A nucleic acid molecule encoding the above-mentioned CAR, as well as a vector and a cell containing it are also disclosed.

EFFECT: invention is effective for the treatment of a mammal suffering from BCMA-expressing cancer.

26 cl, 9 dwg, 4 tbl, 6 ex

Similar patents RU2766608C2

Title	Year	Author	Number
CHIMERIC ANTIGEN RECEPTORS M971	2018	Orentas Rimas Dzh. Pastan, Ira, Kh. Dimitrov Dimiter S. Makkoll Kristal L.	RU2770411C1
METHODS FOR PRODUCING CELLS EXPRESSING CHIMERIC ANTIGEN RECEPTOR	2015	Bedoya Felipe Ghassemi Saba June Carl H. Levine Bruce L. Melenhorst Jan J. Milone Michael C. Powell Daniel J. Jr. Zheng Zoe	RU2751362C2
CD20 THERAPY, CD22 THERAPY AND COMBINATION THERAPY WITH CELLS EXPRESSING CHIMERIC ANTIGEN RECEPTOR (CAR) K CD19	2016	Bitter, Hans Bordeaux,Jennifer, Mary Brannetti, Barbara Brogdon, Jennifer Dakappagari, Naveen, Kumar Gill, Saar Highfill, Steven Huang, Lu June, Carl, H. Kim, Ju, Young Lei, Ming Li, Na Loew, Andreas Orlando, Elena Ruella, Marco Tran, Thai Zhahg, Jimin Zhou, Li	RU2752918C2
GLYCAN-DEPENDENT IMMUNOTHERAPY MOLECULES	2016	Demetriou Majkl Chzhou Rejmond Venkhou	RU2754661C2
TREATMENT OF MALIGNANT NEOPLASM USING HUMANIZED CHIMERIC ANTIGEN RECEPTOR AGAINST BCMA	2015	Brogdon, Jennifer Choi, Eugene Ebersbach, Hilmar Glass, David Huet, Heather June, Carl, H. Mannick, Joan Milone, Michael, C. Murphy, Leon Plesa, Gabriela Richardson, Celeste Ruella, Marco Singh, Reshma Wang, Yongqiang Wu, Qilong	RU2751660C2
COMPOSITIONS AND METHODS FOR SELECTIVE PROTEIN EXPRESSION	2017	Golosov, Andrei Guimaraes, Carla Motz, Gregory Milone, Michael Ellebrecht, Christoph, T. Payne, Aimee, S.	RU2795467C2
T-CELLS MODIFIED WITH CHIMERIC ANTIGEN RECEPTOR TARGETED TO CS1 FOR TREATMENT OF AMYLOIDOSIS AL	2018	Van, Syuli Formen, Stiven Dzh.	RU2774895C2
TREATING CANCER USING A CHIMERIC ANTIGENIC CLL-1 RECEPTOR	2015	Brogdon, Jennifer Ebersbach, Hilmar Gill, Saar Glass, David Jascur, Julia Kenderian, Saad Mannick, Joan Milone, Michael, C. Murphy, Leon Richardson, Celeste Singh, Reshma Wei, Lai Wu, Qilong Yang, Qiumei Zhang, Jiquan	RU2741120C2
CHIMERIC ANTIGENIC (CAR) RECEPTOR AGAINST CD123 FOR USE IN TREATING MALIGNANT TUMORS	2015	Brogdon, Jennifer Gill, Saar Glass, David Kenderian, Saad Loew, Andreas Mannick, Joan Milone, Michael Murphy, Leon Porter, David, L. Ruella, Marco Wang, Yongqiang Wu, Qilong Zhang, Jiquan	RU2724999C2
HUMANIZED ANTIBODY TO BCMA AND BCMA-CAR-T CELLS	2020	Wu, Lijun Golubovskaya, Vita	RU2762942C1

RU 2 766 608 C2

Authors

Kokhenderfer Dzhejms Nobl

Dates

2022-03-15—Published

2013-03-15—Filed