METHOD FOR THE TREATMENT OF PERITONEAL CARCINOMATOSIS IN OVARIAN CANCER Russian patent published in 2021 - IPC A61B17/00 A61B17/94 A61K31/282 A61K31/704 A61P35/00 A61K9/12 

FIELD: oncology.

SUBSTANCE: cytoreduction is performed by performing a lower midline laparotomy with an extension of the incision above the navel. The great omentum is removed, the uterus with the appendages is extirpated, all resectable metastases are removed. Then the vaginal stump is sutured, peritonization is performed. After that, hemostasis is performed in the tumor bed by coagulation and ligation of bleeding vessels. Then, a video endoscopic stage is carried out, for which two trocars are installed: one is installed in the epigastric region, and the other in the hypogastric region. The laparotomic wound is hermetically sutured without installing drains. After sealing the abdominal cavity, carbon dioxide is supplied through the trocar into the abdominal cavity, and a carboxyperitoneum is formed with an intraperional pressure of 12-15 mm Hg. In this case, a laparoscope is introduced through the trocar in the epigastric region; a nozzle is introduced into the hypogastrium through the trocar, which is connected to the injector. By means of an injector, aerosol is sprayed with solutions of cytostatics: cisplatin 10 mg/m² and doxorubicin 2.1 mg/m². Aerosol intra-abdominal chemotherapy is carried out with exposure of a cytostatic aerosol for 30 minutes at an intra-abdominal pressure of 12-16 mm Hg. Upon completion of the exposure, visual control is carried out, if necessary, coagulation hemostasis, carboxyperitoneum is eliminated by means of a vacuum aspirator. Trocars are removed, trocar holes are sutured tightly.

EFFECT: method allows achieving tumor regression in ovarian cancer with peritoneal carcinomatosis, without increasing cytostatic toxicity, due to the simultaneous use of surgical cytoreduction and intra-abdominal aerosol chemotherapy under pressure according to the original scheme.

1 cl, 2 ex