NEURO-ATTENUATING KETAMINE AND NORKETAMINE COMPOUNDS, THEIR DERIVATIVES AND THEIR PRODUCTION METHODS Russian patent published in 2022 - IPC C07C225/20 A61K31/133 C07B59/00 A61P25/02 A61P25/22 A61P25/24 A61P25/28 

FIELD: organic chemistry.

SUBSTANCE: invention relates to the field of organic chemistry, namely to an isotope-enriched norketamine derivative or to its pharmaceutically acceptable salt. The invention also relates to a pharmaceutical composition based on the isotope-enriched norketamine derivative and to its use for inhibiting the activity of NMDA (N-methyl-d-aspartate) receptor.

EFFECT: new norketamine derivatives are obtained with improved half-life and improved bioavailability, useful for the treatment of a disease or condition mediated with NMDA receptor activity.

14 cl, 7 dwg, 3 tbl, 13 ex