FIELD: biotechnologies.
SUBSTANCE: invention relates to genetically modified mice, which express variable human λ (hVλ) sequences, including mice, which express sequence hVλ from endogenous locus light chain λ of mouse, mice, which express sequence hVλ of endogenous locus light chain κ of mouse and mice, which express sequence hVλ of transgene or episome, wherein sequence of hVλ is connected with constant sequence of mouse. Invention relates to mice, which are source of somatically modified variable human sequences λ , suitable for producing of antigen-binding proteins.
EFFECT: invention relates to compositions and methods of producing antigen-binding proteins, which contain variable human sequences λ , including human antibodies.
14 cl, 24 dwg, 8 tbl, 7 ex
| Title | Year | Author | Number |
|---|---|---|---|
| MICE EXPRESSING AN IMMUNOGLOBULIN HYBRID LIGHT CHAIN | 2011 |
|
RU2601297C2 |
| HUMANISED LIGHT CHAIN MICE | 2012 |
|
RU2664181C2 |
| MICE EXPRESSING A LIGHT CHAIN WITH A HUMAN VARIABLE REGION λ AND A CONSTANT MOUSE REGION | 2011 |
|
RU2724736C2 |
| MICE WITH HUMANIZED LIGHT CHAIN | 2012 |
|
RU2761639C2 |
| NON-HUMAN ANIMALS WITH CONSTRUCTED LIGHT CHAIN OF LAMBDA IMMUNOGLOBULIN, AND THEIR USE | 2018 |
|
RU2778410C2 |
| MICE THAT PRODUCE BINDING PROTEINS CONTAINING V DOMAINS | 2011 |
|
RU2750219C2 |
| MOUSE PRODUCING BINDING PROTEINS CONTAINING VL-DOMAINS | 2011 |
|
RU2612903C2 |
| ANIMALS OTHER THAN HUMANS WITH CONSTRUCTED LOCUS OF LIGHT LAMBDA CHAIN OF IMMUNOGLOBULIN | 2017 |
|
RU2757665C2 |
| HUMANIZED GNAWING ANIMALS THAT EXPRESS HEAVY CHAINS CONTAINING V DOMAINS | 2013 |
|
RU2664185C2 |
| HUMANIZED RODENTS WHICH EXPRESS HEAVY CHAINS CONTAINING VDOMAINS | 2013 |
|
RU2770016C2 |
