PACKAGED PRODUCT SUITABLE FOR APPLICATION IN THE ORAL CAVITY Russian patent published in 2022 - IPC A61K31/465 A61K36/185 A61K36/81 A61K47/02 A61K47/26 A61K47/36 A61K47/38 A61K47/46 A61K9/70 

FIELD: medicine.

SUBSTANCE: group of inventions relates to packaged products suitable for application in the oral cavity of a person and containing a closed (sealed) package material. Packaged product for nicotine replacement therapy for treating tobacco addiction comprises a sealed package material containing a filling material containing i) 0 to 10 wt.% cannabis, wherein cannabis constitutes cannabidiol (CBD), tetrahydrocannabinol (THC), cannabinol (CBN), or any stereoisomer, diastereomer or metabolite thereof, ii) up to 10 wt.% nicotine, wherein nicotine is either iia) present in the form of tobacco, or iib) present in the form of pure nicotine and nicotine salt of salicylic acid at a 0.20–1:1 ratio of pure nicotine and salt. The filling material therein additionally contains vi) up to 76 wt.% filler consisting of vi-1) 42 to 60 wt.% microcrystalline cellulose and vi-2) 11 to 22 wt.% potato fibres, wherein the ratio of microcrystalline cellulose (MCC) and potato fibres (PF) is 2.0–4.8:1, and vii) 0.1 to 5 wt.% xanthan gum (XG) as a moistening agent, wherein the ratio between MCC, PF and XG0 is 2.0–4.8:1:0.001–0.4 and wt.% constitute mass percentages of the total mass of the filling material, and up to 100 wt.% of one or more from iii) a sweetener and iv) a pH regulator. Another packaged product is intended for preventing or treating anxiety, cognitive and motor disorders, reducing seizures, insomnia, depression, symptoms of inflammatory bowel disease (IBD), or pain disorders, and contains, as an active component, i) up to 10 wt.% cannabis, wherein cannabis constitutes CBD, THC, CBN, or any stereoisomer, diastereomer, or metabolite thereof, ii) 0 to 10 wt.% nicotine, wherein nicotine is present in the above form (iia) or (iib), in combination with the above filler.

EFFECT: composition of the filler ensures quick initial release of the active component (nicotine and/or cannabis), followed by slow release of substances in 20 to at least 60 minutes; combination of PF, MCC, and XG, taken in certain ratios, provides improved flavour qualities as compared to known products, as well as improved texture and stability of the product, while the moisture content of the product does not change significantly over time.

15 cl, 6 tbl, 4 ex