FIELD: chemistry.
SUBSTANCE: invention relates to methods for producing modified silica gels with covalently immobilized functional groups, which are used as sorption materials for solid-phase extraction, catalyst carriers, materials for immobilization of biologically active compounds, phases for various types of chromatography. A method for producing silica gel with covalently immobilized thiosemicarbazone groups is proposed, which consists in the functionalization of the surface of the aldehyde-silica gel by condensation reaction with thiosemicarbazide, occurring in an ethanol medium in the presence of a catalytic amount of hydrochloric acid and heating at 80°C for 1 hour in accordance with the scheme.
EFFECT: expansion of the range of silica gels functionalized with thiosemicarbazone groups used as multipurpose solid-phase materials.
1 cl, 1 tbl, 4 ex
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