METHOD FOR PREDICTION OF RISK OF DEVELOPMENT OF ACUTE KIDNEY INJURY IN PATIENTS AFTER PARATHYROIDECTOMY FOR PRIMARY HYPERPARATHYROIDISM Russian patent published in 2022 - IPC A61B5/00 G01N33/49 G01N33/493 

FIELD: medicine; internal medicine; endocrinology; nephrology.

SUBSTANCE: invention relates to medicine, namely internal medicine, endocrinology, nephrology; it is intended for prediction of the risk of development of acute kidney injury (hereinafter – AKI) in the early postoperative period after parathyroidectomy (hereinafter – PTE) in patients with primary hyperparathyroidism (hereinafter – PHPT). To do this, before surgery, the presence or absence of arterial hypertension, the fact of taking drugs of a group of angiotensin-converting enzyme inhibitors or angiotensin II receptor blockers, a patient’s body mass index, a level of parathyroid hormone in blood, total calcium in blood, and the presence of proteinuria in the general urine analysis are assessed, a glomerular filtration rate for blood creatinine is calculated using the formula CKD-EPI. Then, the probability of the risk of development of AKI is calculated according to one of original mathematical formulas, depending on the calculated glomerular filtration rate P. With P of more than 58% for the formula 1 and 44.4% for the formula 2, a high risk of development of acute kidney injury is predicted.

EFFECT: method allows for prediction in advance of the development of AKI in patients with PHPT in the postoperative period after PTE, which makes it possible to prevent this complication by improving the preoperative strategy of leading this group of patients, as well as to begin timely treatment in its development.

1 cl, 4 ex