AGENT FOR INHIBITION OF INCREASE IN INTRA-NEURAL CALCIUM CONCENTRATION Russian patent published in 2022 - IPC A61K31/454 A61K31/496 A61P25/00 

FIELD: medicine.

SUBSTANCE: group of inventions relates to inhibition of an increase in an intra-neural calcium concentration. The use of an agent for inhibition of an increase in an intra-neural calcium concentration is disclosed, where the agent includes a cyclic amine derivative of the formula (I) or its pharmaceutically acceptable salt, where A is a group of the formula (IIa), (IIb), or (IIc):

,,

where R¹ is a hydroxyl group or a hydrogen atom, R² is a methyl group, an ethyl group, n-propyl group, an isopropyl group, n-butyl group, a difluoromethyl group, or 2,2,2-trifluoroethyl group, R³ is a hydrogen atom, a fluorine atom, a bromine atom, or a chlorine atom, each R⁴ is independently a methyl group or an ethyl group, n has a value of 1 or 2, when R¹ is a hydroxyl group, carbon marked with *, an asymmetrical carbon atom. The use of a cyclic amine derivative for the treatment or prevention of a disease related to neuron hyperexcitability is also disclosed.

EFFECT: group of inventions provides expansion of the arsenal of means of a specific purpose.

21 cl, 5 tbl, 4 ex